지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 155 - 161 (7page)
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Alzheimer’s disease is the most common neurodegenerative disease and this disease induces progressive loss of memory function Scopol-amine is a non-selective muscarinic cholinergic receptor antagonist and it induces impairment of learning ability. Exercise is known to ame-liorate memory deficits induced by various brain diseases. In the pres-ent study, we investigated the effect of treadmill exercise on spatial learning ability in relation with cell proliferation in the hippocampus us-ing the scopolamine-induced amnesia mice. For the induction of amne-sia, 1 mg/kg scopolamine hydrobromide was administered intraperito-neally once a day for 14 days. Morris water maze test for spatial learn-ing ability was conducted. Immonofluorescence for 5-bromo-2-deoxyu-ridine (BrdU) and western blot for brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase B (TrkB) were performed. In the present results, scopolamine-induced amnesia mice showed deteriora-tion of spatial learning ability. Inhibition of cell proliferation and suppres-sion of BDNF and TrkB expressions were observed in the scopol-amine-induced amnesia mice. Treadmill exercise improved spatial learning ability and increased cell proliferation through activating of BDNF-TrkB pathway in the amnesia mice. These findings offer a possi-bility that treadmill exercise may provide preventive or therapeutic val-ue for the memory loss induced by variable neurodegenerative diseas-es including Alzheimer’s disease.
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참고문헌 (28)
참고문헌 신청
Araujo JA / 2005 / Further evidence for the cholinergic hypothesis of aging and dementia from the canine model of aging / Prog Neuropsychopharmacol Biol Psychiatry 29:411~422
Baek SS / 2012 / Effects of postnatal treadmill exercise on apoptotic neuronal cell death and cell proliferation of maternal separated rat pups / Brain Dev 34:45~56
Cooper-Kuhn CM / 2004 / Decreased neurogenesis after cholinergic forebrain lesion in the adult rat / J Neurosci Res 77:155~165
Cotman CW / 2002 / Exercise: a behavioral intervention to enhance brain health and plasticity / Trends Neurosci 25:295~301
Elvander E / 2004 / Intraseptal muscarinic ligandsand galanin: Influence on hippocampal acetylcholine and cognition / Neuroscience 126:541~557
Baek SS / 2012 / Effects of postnatal treadmill exercise on apoptotic neuronal cell death and cell proliferation of maternal separated rat pups / Brain Dev 34:45~56
Cooper-Kuhn CM / 2004 / Decreased neurogenesis after cholinergic forebrain lesion in the adult rat / J Neurosci Res 77:155~165
Cotman CW / 2002 / Exercise: a behavioral intervention to enhance brain health and plasticity / Trends Neurosci 25:295~301
Elvander E / 2004 / Intraseptal muscarinic ligandsand galanin: Influence on hippocampal acetylcholine and cognition / Neuroscience 126:541~557
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