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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,157 - 1,166 (10page)
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Alteration of apoptosis is related with progression and recurrence of atypical meningiomas (AMs). However, no comprehensive study has been conducted regarding histone modification regulating apoptosis in AMs. This study aimed to determine the prognostic values of certain apoptosis-associated factors, and examine the role of histone modification on apoptosis in AMs. The medical records of 67 patients with AMs, as diagnosed during recent 13 yr, were reviewed retrospectively. Immunohistochemical staining was performed on archived paraffin-embedded tissues for pro-apoptotic factors (CASP3, IGFBP, TRAIL-R1, BAX, and XAF1), anti-apoptotic factors (survivin, ERK, RAF1, MDM2, and BCL2), and the histone modifying enzymes (MLL2, RIZ, EZH1, NSD2, KDM5c, JMJD2a, UTX, and JMJD5). Twenty-six (38.8%) patients recurred during the follow-up period (mean duration 47.7 months). In terms of time-to-recurrence (TTR), overexpression of CASP3, TRAIL-R1, and BAX had a longer TTR than low expression, and overexpression of survivin, MDM2, and BCL2 had a shorter TTR than low expression (P < 0.05). Additionally, overexpression of MLL2, UTX, and JMJ5 had shorter TTRs than low expression, and overexpression of KDM5c had a longer TTR than low expression. However, in the multivariate analysis of predicting factors for recurrence, low expression of CASP3 (P < 0.001), and BAX (P < 0.001), and overexpression of survivin (P = 0.007), and MDM2 (P = 0.037) were associated with recurrence independently, but any enzymes modifying histone were not associated with recurrence. Conclusively, this study suggests certain apoptosisassociated factors should be associated with recurrence of AMs, which may be regulated epigenetically by histone modifying enzymes.
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참고문헌 (48)
참고문헌 신청
Brat DJ / 2008 / Surgical neuropathology update:a review of changes introduced by the WHO classification of tumours of the central nervous system / Arch Pathol Lab Med 132:993~1007
Pearson BE / 2008 / Hitting a moving target: evolution of a treatment paradigm for atypical meningiomas amid changing diagnostic criteria / Neurosurg Focus 24:E3
Rogers L / 2010 / Intracranial meningiomas of atypical(WHO grade II)histology / J Neurooncol 99:393~405
문형식 / 2012 / Intracranial Meningiomas, WHO Grade Il : Prognostic Implications of Clinicopathologic Features / 대한신경외과학회지 52(1):14~20
Marosi C / 2008 / Meningioma / Crit Rev Oncol Hematol 67:153~171
Pearson BE / 2008 / Hitting a moving target: evolution of a treatment paradigm for atypical meningiomas amid changing diagnostic criteria / Neurosurg Focus 24:E3
Rogers L / 2010 / Intracranial meningiomas of atypical(WHO grade II)histology / J Neurooncol 99:393~405
문형식 / 2012 / Intracranial Meningiomas, WHO Grade Il : Prognostic Implications of Clinicopathologic Features / 대한신경외과학회지 52(1):14~20
Marosi C / 2008 / Meningioma / Crit Rev Oncol Hematol 67:153~171
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