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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 991 - 994 (4page)
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초록· 키워드
오류제보하기
Pancreatic islet transplantation is a physiologically advantageous and minimally invasive procedure for the treatment of type 1 diabetes mellitus. Here, we describe the first reported case of successful allogeneic islet transplantation alone, using single-donor, marginal-dose islets in a Korean patient. A 59-yr-old patient with type 1 diabetes mellitus, who suffered from recurrent severe hypoglycemia, received 4,163 islet equivalents/kg from a single brain-death donor. Isolated islets were infused intraportally without any complications. The immunosuppressive regimen was based on the Edmonton protocol, but the maintenance dosage was reduced because of mucositis and leukopenia. Although insulin independence was not achieved, the patient showed stabilized blood glucose concentration, reduced insulin dosage and reversal of hypoglycemic unawareness, even with marginal dose of islets and reduced immunosuppressant. Islet transplantation may successfully improve endogenous insulin production and glycemic stability in subjects with type 1 diabetes mellitus.
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등록된 정보가 없습니다.
참고문헌 (11)
참고문헌 신청
Shapiro AM / 2006 / International trial of the Edmonton protocol for islet transplantation / N Engl J Med 355:1318~1330
Goss JA / 2002 / Achievement of insulin independence in three consecutive type-1 diabetic patients via pancreatic islet transplantation using islets isolated at a remote islet isolation center / Transplantation 74:1761~1766
Yang TY / 2002 / First human trial of pancreatic islet allo-transplantation in Korea--focus on re-transplantation / Diabetes Res Clin Pract 56:107~113
Lee BW / 2005 / The favorable outcome of human islet transplantation in Korea : experiences of 10 autologous transplantations / Transplantation 79:1568~1574
Shapiro AM / 2000 / Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen / N Engl J Med 343:230~238
Goss JA / 2002 / Achievement of insulin independence in three consecutive type-1 diabetic patients via pancreatic islet transplantation using islets isolated at a remote islet isolation center / Transplantation 74:1761~1766
Yang TY / 2002 / First human trial of pancreatic islet allo-transplantation in Korea--focus on re-transplantation / Diabetes Res Clin Pract 56:107~113
Lee BW / 2005 / The favorable outcome of human islet transplantation in Korea : experiences of 10 autologous transplantations / Transplantation 79:1568~1574
Shapiro AM / 2000 / Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen / N Engl J Med 343:230~238
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