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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 569 - 575 (7page)
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초록· 키워드
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This study sought to assess the relationship between serum concentrations of the soluble ST2 (sST2) and B-type natriuretic peptide (BNP) and investigate the role of sST2 as a prognosticator in patients hospitalized with acute heart failure (HF) and renal insufficiency.
sST2 was measured at admission and discharge in 66 patients hospitalized with acute decompensated HF and renal insufficiency (estimated glomerular filtration rate [eGFR] < 90 mL/min/1.73 m2) using a high sensitivity immunoassay. BNP was sampled at the same time and compared to sST2. Demographical, biochemical, and echocardiographic data were also obtained during hospitalization.There were positive correlations between sST2 and BNP levels at admission (r = 0.330, P = 0.007) and at discharge (r = 0.320, P = 0.009) in overall patients. However, there was no correlation between them at each timepoint in patients with severe renal insufficiency (eGFR < 30 mL/min/1.73 m2, n = 17). sST2 level was not changed with the degree of renal function, even though BNP level was much higher in patients with severe renal insufficiency. During 3 month follow-up, 9 (13.6%) died and 16 (24.2%) were readmitted due to HF aggravation.On multivariate analysis, sST2 at discharge was independently associated with death or HF readmission during 3 months after discharge (hazard ratio, 1.038; 95% confidence interval, 1.011-1.066, P = 0.006).
In conclusion, sST2 is not affected by renal function compared with BNP in acute HF patients. The measurement of predischarge sST2 can be helpful in predicting short-term outcomes in acute decompensated HF patients with renal insufficiency.
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등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Levin ER / 1998 / Natriuretic peptides / N Engl J Med 339:321~328
Daniels LB / 2007 / Natriuretic peptides / J Am Coll Cardiol 50:2357~2368
Anwaruddin S / 2006 / Renal function, congestive heart failure, and amino-terminal pro-brain natriuretic peptide measurement: results from the ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) Study / J Am Coll Cardiol 47:91~97
Richards M / 2006 / Comparison of B-type natriuretic peptides for assessment of cardiac function and prognosis in stable ischemic heart disease / J Am Coll Cardiol 47:52~60
McCullough PA / 2003 / B-type natriuretic peptide and renal function in the diagnosis of heart failure: an analysis from the Breathing Not Properly Multinational Study / Am J Kidney Dis 41:571~579
Daniels LB / 2007 / Natriuretic peptides / J Am Coll Cardiol 50:2357~2368
Anwaruddin S / 2006 / Renal function, congestive heart failure, and amino-terminal pro-brain natriuretic peptide measurement: results from the ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) Study / J Am Coll Cardiol 47:91~97
Richards M / 2006 / Comparison of B-type natriuretic peptides for assessment of cardiac function and prognosis in stable ischemic heart disease / J Am Coll Cardiol 47:52~60
McCullough PA / 2003 / B-type natriuretic peptide and renal function in the diagnosis of heart failure: an analysis from the Breathing Not Properly Multinational Study / Am J Kidney Dis 41:571~579
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