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자료유형
학술저널
저자정보
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.30 No.3
발행연도
2015.1
수록면
290 - 295 (6page)

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초록· 키워드

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This study aimed to evaluate the efficacy of random-start controlled ovarian stimulation(COS) in cancer patients for emergency fertility preservation. In this retrospectivecomparative study, 22 patients diagnosed with cancer and 44 infertile women undergoingconventional in vitro fertilization (IVF) were included. In cancer patients, ovarianstimulation was started on the day of referral, irrespective of their menstrual cycle date. The control group was selected by age matching among women undergoing conventionalIVF. COS outcomes were compared between groups. The number of total and matureoocytes retrieved and the oocyte maturity rate were higher in the random-start group thanin the conventional-start group. However, duration of ovarian stimulation was longer inthe random-start group (11.4 vs. 10.3 days, P = 0.004). The addition of letrozole to lowerthe estradiol level during COS did not adversely affect total oocytes retrieved. However,oocyte maturity rate was lower in cycles with letrozole than in cycles without letrozole(71.6% vs. 58.2%, P = 0.019). Our study confirms the feasibility and effectiveness ofrandom-start COS in cancer patients.

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