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Purpose: We examined whether fractional exhaled nitric oxide (FeNO) levels are associated with atopy profiles in terms of mono-sensitization andpoly-sensitization in asthmatic children. Methods: A total of 119 children underwent an assessment that included FeNO measurements, spirometry,methacholine challenge, and measurement of blood eosinophil count, serum total IgE, and serum eosinophil cationic protein (ECP). We also examinedsensitization to five classes of aeroallergens (house dust mites, animal danders, pollens, molds, and cockroach) using skin prick testing. Thechildren were divided into three groups according to their sensitization profiles to these aeroallergens (non-sensitized, mono-sensitized, and polysensitized). Results: The geometric means (range of 1 SD) of FeNO were significantly different between the three groups (non-sensitized, 18.6 ppb[10.0-34.7 ppb]; mono-sensitized, 28.8 ppb [16.6-50.1 ppb]; and poly-sensitized, 44.7 ppb [24.5-81.3 ppb], P=0.001). FeNO levels were correlatedwith serum total IgE concentrations, peripheral blood eosinophilia, and serum ECP levels to different degrees. Conclusions: FeNO levels vary accordingto the profile of atopy, as determined by positive skin prick test results to various classes of aeroallergens. FeNO is also moderately correlatedwith serum total IgE, blood eosinophilia, and serum ECP. These results suggest that poly-sensitized asthmatic children may have the highest riskof airway inflammation.

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