지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.4 No.3
- 발행연도
- 2012.1
- 수록면
- 150 - 156 (7page)
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초록· 키워드
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Purpose: Probiotic bacteria can induce immune regulation or immune tolerance in allergic diseases. The underlying mechanisms have been recently investigated, but are still unclear. The aim of this study was to evaluate the protective effects of the probiotic Lactobacillus rhamnosus (Lcr35) in a mouse model of asthma and to identify its mechanism of action. Methods: Lcr35 was administered daily by the oral route at a dosage of 1×109CFU/mouse in BALB/c mice for 7 days before the first sensitization. Clinical parameters and regulatory T (Treg) cells were examined. The role of CD4+CD25+Foxp3+ Treg cells was analyzed using a Treg cell-depleting anti-CD25 monoclonal antibody (mAb). Results: Airway hyperresponsiveness,total IgE production, pulmonary eosinophilic inflammation, and splenic lymphocyte proliferation were suppressed after Lcr35 treatment. Th1(IFN-γ) and Th2 (IL-4, IL-5, and IL-13) cytokines in the serum were suppressed, and the percentage of CD4+CD25+Foxp3+ Treg cells in the spleen was significantly increased in the Lcr35 treatment group. Anti-CD25 mAb administration abolished the protective effects of Lcr35, indicating that CD4+CD25+Foxp3+ Treg cells are essential in mediating the activity of Lcr35. Conclusions: Oral administration of Lcr35 attenuated the features of allergic asthma in a mouse model and induced immune regulation by a CD4+CD25+Foxp3+ Treg cell-mediated mechanism.
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참고문헌 (23)
참고문헌 신청
Marteau P / 2006 / Probiotics, prebiotics, synbiotics: ecological treatment for inflammatory bowel disease? / Gut 55:1692~1693
Kwon HK / 2010 / Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders / Proc Natl Acad Sci U S A 107:2159~2164
Macpherson AJ / 2004 / Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria / Science 303:1662~1665
Huang FP / 2000 / A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes / J Exp Med 191:435~444
Feleszko W / 2007 / Probiotic- induced suppression of allergic sensitization and airway inflammation is associated with an increase of T regulatory-dependent mechanisms in a murine model of asthma / Clin Exp Allergy 37:498~505
Kwon HK / 2010 / Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders / Proc Natl Acad Sci U S A 107:2159~2164
Macpherson AJ / 2004 / Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria / Science 303:1662~1665
Huang FP / 2000 / A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes / J Exp Med 191:435~444
Feleszko W / 2007 / Probiotic- induced suppression of allergic sensitization and airway inflammation is associated with an increase of T regulatory-dependent mechanisms in a murine model of asthma / Clin Exp Allergy 37:498~505
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