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논문 기본 정보

자료유형
학술저널
저자정보
김성배 (울산대학교) Yau Tsz Kok (Pamela Youde Nethersole Eastern Hospital) Tran Van Thuan (National Cancer Hospital) Tsu-Yi Chao (Tri-Service General Hospital) Zhen Zhou Shen (Shanghai Fudan University Cancer Hospital)
저널정보
한국유방암학회 Journal of Breast Cancer Journal of Breast Cancer Vol.18 No.4
발행연도
2015.1
수록면
356 - 364 (9page)

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Purpose: The goal of this registry was to collect patient characteristics and safety data from patients from the Asia-Pacific region with early breast cancer receiving adjuvant chemotherapy containing docetaxel (Taxotere®). Methods: This registry was open-label, international, longitudinal, multicenter, and observational in design and included a prospective group of consecutive early breast cancer patients with an intermediate-to-high risk of recurrence being treated with various docetaxel-based (anthracycline and non-anthracycline) adjuvant chemotherapy regimens during 2009–2013 in real-world clinical settings. Results: The analysis included 1,712 patients, 79% of whom received docetaxel-based, anthracycline-containing regimens, while 21% received non-anthracycline-containing regimens. Patients receiving adjuvant docetaxel-based chemotherapy were followed for 1.5 years. Chemotherapy-related adverse events (AEs) were reported by 76.2% of patients (anthracycline-containing vs. nonanthracycline- containing regimens: 76.8% vs. 74.1%). Serious AEs were reported in 12% of patients (12.3% vs. 10%). National Cancer Institute Common Terminology Criteria for Adverse Events grade 3 or higher neutropenia was reported in 20% of patients (21.6% vs. 13.9%), leukopenia in 7.4% of patients (5.4% vs. 14.8%), and vomiting in 1.6% of patients (1.8% vs. 0.6%). Treatment-related death was reported in 27 patients (1.6%), while only 3% of patients had a relapse. Low-density lipoprotein cholesterol/high-density lipoprotein cholesterol (HDL-C) and total cholesterol/HDL-C ratios increased after chemotherapy. A clinically insignificant reduction of 1.9% in left ventricular ejection fraction, from 66.43 to 64.53, was observed 1.5 years after therapy was completed. Conclusion: The Asia-Pacific Breast initiative II registry identified a variety of important facts regarding patient population characteristics, disease epidemiology and treatment response for early breast cancer patients of the Asia-Pacific region receiving docetaxel-based chemotherapy. Docetaxel-based chemotherapy did not show any significant safety concerns for early breast cancer patients of the Asia- Pacific region, and thus may represent a safe adjuvant chemotherapy regimen for these patients.

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참고문헌 (34)

참고문헌 신청
Resetkova E / 2010 / Prognostic impact of ALDH1 in breast cancer : a story of stem cells and tumor microenvironment / Breast Cancer Res Treat 123:97~108 google schola Tsang JY / 2012 / Cancer stem cell markers are associated with adverse biomarker profiles and molecular subtypes of breast cancer / Breast Cancer Res Treat 136:407~417 google schola Ginestier C / 2007 / ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome / Cell Stem Cell 1:555~567 google schola Croker AK / 2008 / Cancer stem cells : implications for the progression and treatment of metastatic disease / J Cell Mol Med 12:374~390 google schola Chuthapisith S / 2010 / Breast cancer chemoresistance : emerging importance of cancer stem cells / Surg Oncol 19:27~32 google schola

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