Risk Factors Associated with Distant Metastasis and Survival Outcomes in Breast Cancer Patients with Locoregional Recurrence

박수진; 한원식; 김종진; 김민균; 이은신; 유태경; 이한별; 강영준; 김윤경; 문형곤; 노동영

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자료유형: 학술저널

저자정보: 박수진 (국립암센터) 한원식 (서울대학교) 김종진 (서울특별시보라매병원) 김민균 (강원대학교병원) 이은신 (분당제생병원) 유태경 (서울대학교) 이한별 (서울대학교병원) 강영준 (서울대학교) 김윤경 (원자력병원) 문형곤 (서울대학교) 노동영 (서울대학교)

저널정보: 한국유방암학회 Journal of Breast Cancer Journal of Breast Cancer Vol.18 No.2

발행연도: 2015.1

수록면: 160 - 166 (7page)

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Purpose: To decide the optimal treatment for breast cancer patients with locoregional recurrence (LRR), it is important to determine which group has the highest risk of subsequent distant metastasis (DM). We aimed to investigate the factors associated with DM in patients with LRR. Methods: We reviewed the data of 208 patients with LRR as the first event after primary surgery for breast cancer at our institution between 1997 and 2010, to identify significant factors associated with DM. Subsequently, Kaplan-Meier curves and the Cox regression method were used to analyze the correlation between clinical factors and survival. Results: DM occurred in 33.2% (68/208) of LRR patients. The median DM-free interval was 23 months. Some clinical factors were associated with DM in univariate analysis, including the type of primary surgery (p=0.026), tumor size (p=0.005), nodal status (p=0.011), and administration of initial adjuvant chemotherapy (p=0.001). In addition, regional rather than local recurrence and a disease-free interval (DFI; duration between primary surgery and LRR) ≤30 months were also significant (p<0.001 for both). However, only a shorter DFI reached significance in multiple logistic regression analysis. Cox regression analysis of DM-free survival showed that both a shorter DFI and regional recurrence were significant factors with hazard ratios of 2.1 (95% confidence interval [CI], 1.21–3.65) and 1.85 (95% CI, 1.04–3.28), respectively. Conclusion: DFI was the most important factor associated with subsequent DM in patients with LRR as a first event of failure.

참고문헌 (30)

참고문헌 신청

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Stathopoulos GP / 2014 / The role of Ki-67 in the proliferation and prognosis of breast cancer molecular classification subtypes / Anticancer Drugs 25:950~957

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