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Vitamin D Receptor Poly(A) Microsatellite Polymorphism and 25-Hydroxyvitamin D Serum Levels: Association with Susceptibility to Breast Cancer
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논문 기본 정보

Type
Academic journal
Author
Abasalt Hossienzadeh Colagar (University of Mazandaran Faculty of Basic Sciences) Hamid Moradi Firouzjah (University of Mazandaran Faculty of Basic Sciences) Sohrab Halalkhor (Babol University of Medical Sciences)
Journal
한국유방암학회 Journal of Breast Cancer Journal of Breast Cancer Vol.18 No.2 KCI Accredited Journals
Published
2015.1
Pages
119 - 125 (7page)

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Vitamin D Receptor Poly(A) Microsatellite Polymorphism and 25-Hydroxyvitamin D Serum Levels: Association with Susceptibility to Breast Cancer
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Abstract· Keywords

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Purpose: According to previous studies, vitamin D exhibits protective effects against breast cancer via the vitamin D receptor (VDR). There is growing evidence that breast cancer incidence is associated with various polymorphisms of the VDR gene. This study investigates the association of VDR poly(A) microsatellite variants with 25-hydroxyvitamin D (25(OH)D) serum levels and breast cancer risk. Methods: Polymorphism analysis was performed on a total of 261 blood samples, which were collected from 134 women with breast cancer and 127 controls. Single strand conformation polymorphism was assessed by polymerase chain reaction in combination with sequencing to detect poly(A) lengths for each sample. The vitamin D levels of samples were determined by electrochemiluminescence. Results: The poly(A) variant L allele frequency was significantly higher in cancer patients than in controls (odds ratio [OR], 1.73; 95% confidence interval [CI], 1.16–2.57; p=0.006). Thus, carriers of the L allele (LS and LL genotypes) have a higher risk for breast cancer (OR, 1.86; 95% CI, 1.13–3.05; p=0.013). A larger increase in the risk for breast cancer was found in individuals with the L carrier genotype and lowered 25(OH)D levels. Conclusion: The results primarily suggest that VDR gene polymorphism in the poly(A) microsatellite is associated with 25(OH)D levels and that it can affect the breast cancer risk in the female population from northern Iran.

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References (30)

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Rezaianzadeh A / 2011 / Prevalence of breast cancer in a defined population of iran / Iran Red Crescent Med J 13:647~650 google schola Naghibi A / 2013 / Early detection of breast cancer among women in Mazandaran, Iran / IJHS 1:44~49 google schola Taghavi A / 2012 / Increased trend of breast cancer mortality in Iran / Asian Pac J Cancer Prev 13:367~370 google schola Fang L / 2011 / Targeted therapy in breast cancer: what's new? / Swiss Med Wkly 141:w13231 google schola Vogelstein B / 2004 / Cancer genes and the pathways they control / Nat Med 10:789~799 google schola

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