지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 363 - 369 (7page)
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초록· 키워드
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Purpose: In the present study, we investigated the incidence ofcardiotoxicity within 5 years of trastuzumab treatment and evaluatedpotential risk factors in clinical practice. Methods: The studycohort included 415 patients diagnosed with early breast cancer(EBC). Cardiotoxicity incidence was evaluated in patients receivingtrastuzumab and those who did not. Multivariate Cox proportionalhazards regression models were used to estimate hazardratios and 95% confidence intervals of potential risk factorsfor trastuzumab-related cardiotoxicity after appropriate adjustments.
Results: Incidence of cardiotoxicity in patients treatedwith trastuzumab was significantly higher than that in controls(23.7% vs. 10.8%, p<0.001). This result was adjusted for factorsthat might increase the risk of cardiotoxicity, such as historyof coronary artery diseases or the use of anthracyclines for morethan four cycles. Conclusion: Our findings indicated that treatmentwith trastuzumab was strongly associated with cardiotoxicityin EBC patients.
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참고문헌 (18)
참고문헌 신청
Piccart-Gebhart MJ / 2005 / Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer / N Engl J Med 353:1659~1672
Slamon DJ / 2001 / Use of chemotherapy plus a monoclonal antibody against HER2for metastatic breast cancer that overexpresses HER2 / N Engl J Med 344:783~792
Tarantini L / 2012 / Adjuvant trastuzumab cardiotoxicity in patients over 60 years of age with early breast cancer: a multicenter cohort analysis / Ann Oncol 23:3058~3063
Seidman A / 2002 / Cardiac dysfunction in the trastuzumab clinical trials experience / J Clin Oncol 20:1215~1221
Perez EA / 2008 / Cardiac safety analysis of doxorubicin and cyclophosphamide followed by paclitaxel with or without trastuzumab in the North Central Cancer Treatment Group N9831 adjuvant breast cancer trial / J Clin Oncol 26:1231~1238
Slamon DJ / 2001 / Use of chemotherapy plus a monoclonal antibody against HER2for metastatic breast cancer that overexpresses HER2 / N Engl J Med 344:783~792
Tarantini L / 2012 / Adjuvant trastuzumab cardiotoxicity in patients over 60 years of age with early breast cancer: a multicenter cohort analysis / Ann Oncol 23:3058~3063
Seidman A / 2002 / Cardiac dysfunction in the trastuzumab clinical trials experience / J Clin Oncol 20:1215~1221
Perez EA / 2008 / Cardiac safety analysis of doxorubicin and cyclophosphamide followed by paclitaxel with or without trastuzumab in the North Central Cancer Treatment Group N9831 adjuvant breast cancer trial / J Clin Oncol 26:1231~1238
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