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자료유형
학술저널
저자정보
Wenguang Li (University of Glasgow)
저널정보
대한의용생체공학회 Biomedical Engineering Letters (BMEL) Biomedical Engineering Letters (BMEL) Vol.5 No.4
발행연도
2015.1
수록면
241 - 250 (10page)

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Propose In vitro biomechanical properties of the skin are ofimportant to cosmetic product development, plastic surgery,surgical practice, skin disease pathology, mechanical traumaand artificial skin design. However, complex biomechanicalproperties of the skin have not been fully understood so far. The literature of histology, in vitro biomechanical propertiesand modelling methods of the skin is reviewed to identifyimportant problems that need to be tackled. Methods A PubMed literature search was conducted usingthe terms ‘skin,’ ‘biomechanical property,’ ‘damage,’ ‘collagenfibre,’ ‘viscoelastic’ and ‘dermis.’ Relevant papers were readand analysed. Results The histology of the skin has been studiedconsiderably by means of optical and electron microscopies. The collagen fibre structure in the dermis has been observedwith image analysis approach, and a few formulas for fibreorientation dispersion are proposed. The uniaxial, biaxial andbulge test methods were commonly applied to determinein vitro biomechanical properties of the skin. In vitrobiomechanical properties exhibit nonlinear anisotropicbehaviour, and at a higher strain rate, there is damage effect. Simple elongation model, isotropic model, collagen fibrerecruitment model and micro-structure based model areapplicable for the skin. The biomechanical property constantscan be determined from the stress-stretch curves obtained inuniaxial or biaxial or multi-axial or bulge tests. Conclusions The collagen fibre network 3D structure remainunclear and the fibre orientation dispersion characteristics arenot totally understood. The damage effect in the skin has notbeen tackled by using constitutive laws so far. The tensiledamage and fracture process, multi-layer biomechanicalmodels developing, viscoelastic property testing and modelling

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