Purpose: This concept analysis was performed to clarify “stress in hemodialysis patients”. Methods: Walker and Avant’s methodology guided the analysis. In addition, the concept was compared with stress from other perspectives. Results: Stress in hemodialysis patients was defined in terms of “Physical”, “Psychological”, “Social ‧ Economic”, and “Behavioral” dimensions. Stress in hemodialysis patients is preceded by kidney failure, fear of treatment, and uncertainty about prognosis, after which there is often negative coping such as non-compliance with treatment, or positive coping such as maintaining the status quo, relying on medical staff, conforming to treatment, and self-management. Conclusion: It is necessary to develop a stress intervention program suitable for hemodialysis patients and a tool to identify the concept of stress in hemodialysis patients suitable for domestic situations, as well as conduct further research to identify its influencing factors.