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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.11
- 수록면
- 236 - 236 (1page)
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초록· 키워드
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Short-chain fatty acids (SCFAs), the major end products of fermentation of dietary fibers by gut microbiota, change their levels in a biological system reflect the progress of various diseases. In addition, the tricarboxylic acid (TCA) cycle is central to carbon metabolism and energy production in all aerobic organisms and consists of eight low molecular weight polar intermediates such as ketoglutaric acid, citric acid, malic acid, succinic acid, fumaric acid, and oxaloacetic acid. Development of analytical method is needed to effectively profile SCFAs and TCA cycle intermediates in complex biological samples. However, accurate determination of SCFAs in biological samples is not easy task due to their easy loss during sample workup causing to their high volatility and hydrophilicity, and the coexistence of interference. Furthermore, carboxylate groups of TCA cycle intermediates are liable to decarboxylation under basic conditions or high temperature. In t ... 전체 초록 보기
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