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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.11
- 수록면
- 138 - 138 (1page)
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이 논문의 연구 히스토리 (5)
2020
Raman spectroscopic analysis of kidney tissue in chronic kidney disease (CKD) model
Shokhid Gulyamov
,
Maftuna Shamshiddinova
,
Hee-Jung Kim
외 2명
한국분석과학회 학술대회
2020.11
학술대회자료
LC-MS/MS analysis of ceramide in Chronic kidney disease (CKD) model induced by adenine
Shokhid Gulyamov
,
Maftuna Shamshiddinova
,
Naz
외 4명
한국분석과학회 학술대회
2020.06
학술대회자료
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초록· 키워드
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Psoriasis is a chronic inflammatory skin disease and immune-mediated disease. Several psoriasis animal models have been developed. Sphingolipids have been known to regulate the biological functions and immune cells in skin. In this study, ceramide analysis by LC-MS/MS and inhibition of SphK1 by PF543 in IMQ-induced psoriasis mouse model were investigated.
8-week-old BALB/c mice were housed. The mice were divided into four groups: Vaseline treated control group, imiquimod-treated psoriasis group (IMQ) (3.125 mg/mouse), IMQ plus PF-543 group (1 mg/kg), IMQ plus ethanol group. On the 10<SUP>th</SUP> day, mice were sacrificed to collect plasma, spleen, and skins samples.
The ceramides from plasma and back skin samples were extracted by chloroform: methanol (2:1) mixture. The chloroform phase was dried at a vacuum evaporator and the dry residue was reconstituted in 100 μl MeOH before injecting into LC-MS/MS. The samples were eluted from CAPCELL PAK MG III C18 column with gradient elution with mobile phase A (10 mM ammonium acetate in water with 0.1% formic acid) and mobile phase ... 전체 초록 보기
8-week-old BALB/c mice were housed. The mice were divided into four groups: Vaseline treated control group, imiquimod-treated psoriasis group (IMQ) (3.125 mg/mouse), IMQ plus PF-543 group (1 mg/kg), IMQ plus ethanol group. On the 10<SUP>th</SUP> day, mice were sacrificed to collect plasma, spleen, and skins samples.
The ceramides from plasma and back skin samples were extracted by chloroform: methanol (2:1) mixture. The chloroform phase was dried at a vacuum evaporator and the dry residue was reconstituted in 100 μl MeOH before injecting into LC-MS/MS. The samples were eluted from CAPCELL PAK MG III C18 column with gradient elution with mobile phase A (10 mM ammonium acetate in water with 0.1% formic acid) and mobile phase ... 전체 초록 보기
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