지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 7 - 15 (9page)
이용수
초록· 키워드
오류제보하기
Background:Targeted temperature management (TTM) has neuroprotective effects in comatose patients despite restoration of spontaneous circulation (ROSC) after out-of-hospital cardiac arrest. However, no TTM trials have been performed for in-hospital cardiac arrest (IHCA). Methods:We aim to enroll 60 comatose adults with ROSC after IHCA. Eligible patients are randomly assigned in a 2:1 ratio to either the intervention group or the control group with stratification according to the electrocardiography rhythm. Core body temperature is maintained at 36 °C for the initial 72 hours (TTM-36) in the intervention group. Fever control using conventional methods is attempted in the control group. The primary efficacy outcome is Cerebral Performance Category (CPC) of 3-5 at 180 days. The secondary efficacy outcomes include CPC of 3-5 at 7 days and 30 days; modified Rankin Scale of 4-6 at 7 days, 30 days, and 180 days; daily measured serum levels of neuron specific enolase for the first 5 days; predefined electroencephalography patterns suggesting poor prognosis; repeated measurements of brain MRI including diffusion-weighted imaging, fluid attenuated inversion recovery, susceptibility-weighted imaging, high resolution T1-weighted imaging, diffusion tensor imaging, and resting state functional MRI at 4 days, 30 days, and 180 days; detailed neuropsychological tests; questionnaire for depression, quality of life, activities of daily living, and neuropsychiatric symptoms; and scales for parkinsonism and ataxia. The safety outcomes include cardiac re-arrest, arrhythmia, pneumonia, septic shock, infection, bleeding, and shivering. Results:We are currently recruiting the study patients. Conclusion:The results of this trial are expected to provide evidence for feasibility, safety, and efficacy of TTM-36 in patients with IHCA.
목차
등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Booth CM / 2004 / Is this patient dead, vegetative, or severely neurologically impaired? Assessing outcome for comatose survivors of cardiac arrest / JAMA 291:870~879
Holzer M / 2010 / Targeted temperature management for comatose survivors of cardiac arrest / N Engl J Med 363:1256~1264
Zandbergen EG / 2003 / Survival and recovery of consciousness in anoxic-ischemic coma after cardiopulmonary resuscitation / Intensive Care Med 29:1911~1915
Peberdy MA / 2010 / Part 9: Post-cardiac arrest care: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care / Circulation 122(18 Suppl 3):S768~S786
Busl KM / 2010 / Hypoxic-ischemic brain injury: pathophysiology, neuropathology and mechanisms / NeuroRehabilitation 26:5~13
Holzer M / 2010 / Targeted temperature management for comatose survivors of cardiac arrest / N Engl J Med 363:1256~1264
Zandbergen EG / 2003 / Survival and recovery of consciousness in anoxic-ischemic coma after cardiopulmonary resuscitation / Intensive Care Med 29:1911~1915
Peberdy MA / 2010 / Part 9: Post-cardiac arrest care: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care / Circulation 122(18 Suppl 3):S768~S786
Busl KM / 2010 / Hypoxic-ischemic brain injury: pathophysiology, neuropathology and mechanisms / NeuroRehabilitation 26:5~13
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Targeted temperature management for postcardiac arrest syndrome
Journal of Neurocritical Care
2020 .01
-
Overview of in-hospital cardiac arrests in a 3-year period
Journal of Biomedical and Translational Research
2023 .06
-
Targeted Temperature Management with Hypothermia for Comatose Patients After Cardiac Arrest
Clinical and Experimental Emergency Medicine
2023 .03
-
Incidence of Adult In-Hospital Cardiac Arrest Using National Representative Patient Sample in Korea
Healthcare Informatics Research
2016 .01
-
요양병원과 비요양병원에 입원한 노인환자에게 시행된 심폐소생술의 역학적 특징과 결과의 비교: 건강보험심사평가원 자료기반
대한응급의학회지
2015 .01
-
Targeted temperature management in a patient with suspected hypoxic-ischemic brain injury after successful resuscitation from cardiac arrest: a case report
고신대학교 의과대학 학술지
2023 .06
-
Association between the D-dimer to fibrinogen ratio and neurological outcomes in patients with witnessed out-of-hospital cardiac arrest treated with targeted temperature management
대한응급의학회지
2024 .08
-
목표 체온 조절 치료를 받은 심정지 환자에서의 예후 평가 도구로서 뇌 MRI T2 weighted image에서의 회색질과 백색질 신호 강도 비의 유용성: 선행연구
대한응급의학회지
2019 .01
-
Use of amplitude-integrated electroencephalography in decision-making for extracorporeal membrane oxygenation in comatose cardiac arrest patients whose eventual neurologic recovery is uncertain
Clinical and Experimental Emergency Medicine
2019 .01
-
노인 심정지 환자의 자발순환 회복 및 생존에 대한 예후 인자 분석
Annals of geriatric medicine and research
2015 .01
-
Comparison between Gel Pad Cooling Device and Water Blanket during Target Temperature Management in Cardiac Arrest Patients
Acute and Critical Care
2018 .01
-
심정지 여부에 따른 목맴 환자의 특징과 예후인자로서의 S100B 단백질의 유용성
대한응급의학회지
2015 .01
-
Recent Update in Out-of-Hospital Cardiac Arrests in Korea
Korean Circulation Journal
2021 .10
-
출동 거리에 따른 병원 전 심장정지 환자의 자발순환회복률 분석
한국응급구조학회지
2017 .08
-
Brain Magnetic Resonance Imaging in Patients with Favorable Outcomes after Out-of-Hospital Cardiac Arrest: Many Have Encephalopathy Even with a Good Cerebral Performance Category Score
Acute and Critical Care
2015 .01
-
Spatiotemporal Analysis of Out-of-Hospital Cardiac Arrest Incidence and Survival Outcomes in Korea (2009–2021)
Journal of Korean Medical Science
2024 .03
-
병원 밖 심정지에서 현장의 수직 위치와 기계심폐소생장치가 소생 결과에 미치는 영향에 대한 관찰연구
대한응급의학회지
2016 .01
-
Complete Recovery of Perfusion Abnormalities in a Cardiac Arrest Patient Treated with Hypothermia: Results of Cerebral Perfusion MR Imaging
Investigative Magnetic Resonance Imaging
2018 .01
-
Moderate to Severe Left Ventricular Ejection Fraction Related to Short-term Mortality of Patients with Post-cardiac Arrest Syndrome after Out-of-Hospital Cardiac Arrest
Acute and Critical Care
2016 .01
-
Main outcomes of the Sudden cardiac arrest survey 2006 to 2016
Clinical and Experimental Emergency Medicine
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0