Comparison of the antigenic relationship between Japanese encephalitis virus genotypes 1 and 3

강보규; 황정민; 문형준; 한상윤; 김종만; 양동근; 박봉균; 송대섭

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자료유형: 학술저널

저자정보: 강보규 (녹십자수의약품 (주)) 황정민 (녹십자수의약품 (주)) 문형준 (녹십자수의약품 (주)) 한상윤 (녹십자수의약품 (주)) 김종만 (녹십자수의약품 (주)) 양동근 (농림축산검역본부) 박봉균 (서울대학교) 송대섭 (고려대학교)

저널정보: 대한백신학회 Clinical and Experimental Vaccine Research Clinical and Experimental Vaccine Research Vol.5 No.1

발행연도: 2016.1

수록면: 26 - 30 (5page)

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Purpose: The Japanese encephalitis virus (JEV) genotype circulating in Korea has changed from G3 to G1. Therefore, the purpose of this study was to compare the antigenic relationship between the two genotypes by using antibody tests. Materials and Methods: Blood samples from 42 sows and 216 horses were collected, and their seroprevalence was monitored using the hemagglutination inhibition and virus neutralization tests. Antisera against JEV G1 and G3 were isolated and prepared from guinea pigs. The cross-reactivity of these two viruses was then compared using the neutralizing antibody test. Results: We found that there was a difference in the seropositive ratios of JEV G1 and G3. However, the difference was dependent on the antibody test used. There was also an observed difference in the antigenicity between the two genotypes, as ascertained using the neutralizing antibody test. Conclusion: There is an evident difference in JEV antigenicity between the genotypes G1 and G3. Therefore, we propose monitoring of the seroprevalence of JEV, and reevaluating the antigenicity of the current vaccine by using the relevant tests.

참고문헌 (23)

참고문헌 신청

Gubler DJ / 2007 / The continuing spread of West Nile virus in the western hemisphere / Clin Infect Dis 45:1039~1046

Erlanger TE / 2009 / Past, present, and future of Japanese encephalitis / Emerg Infect Dis 15:1~7

Han N / 2014 / Comparison of genotypes I and III in Japanese encephalitis virus reveals distinct differences in their genetic and host diversity / J Virol 88:11469~11479

Schuh AJ / 2013 / Phylogeography of Japanese encephalitis virus: genotype is associated with climate / PLoS Negl Trop Dis 7:e2411

Schuh AJ / 2014 / Dynamics of the emergence and establishment of a newly dominant genotype of Japanese encephalitis virus throughout Asia / J Virol 88:4522~4532

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