지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 139 - 144 (6page)
이용수
초록· 키워드
오류제보하기
Objective Cognitive impairment is one of the nonmotor symptoms in Parkinson’s disease (PD), and olfactory dysfunction is used as a marker to detect premotor stages of PD. Serum uric acid (sUA) levels have been found to be a risk factor for PD. Our objective in this study was to examine whether sUA levels are associated with cognitive changes and olfactory dysfunction in early de novo PD patients. Methods The study participants included 196 de novo PD patients. We assessed cognitive function by the Korean versions of the Mini-Mental State Examination and the Montreal Cognitive Assessment and assessed olfactory function by the Korean version of the Sniffin’ Sticks test. Results The mean sUA level was 4.7 mg/dL and was significantly lower in women than in men. Cognitive scores were lower in women, suggesting that sUA levels were related to cognitive function. The olfactory functions were not related to sUA level but were clearly associated with cognitive scores. Olfactory threshold, odor discrimination, and odor identification were all significantly related to cognitive scores. Conclusion We conclude that lower sUA levels were associated with cognitive impairment, not olfactory dysfunction, in de novo PD patients. This finding suggests that UA is neuroprotective as an antioxidant in the cognitive function of PD patients.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Domellof ME / 2017 / Olfactory dysfunction and dementia in newly diagnosed patients with Parkinson's disease / Parkinsonism Relat Disord 38:41~47
Casjens S / 2013 / Diagnostic value of the impairment of olfaction in Parkinson's disease / PLoS One 8:e64735
Hughes TA / 2000 / A 10-year study of the incidence of and factors predicting dementia in Parkinson's disease / Neurology 54:1596~1602
Fang J / 2000 / Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971-1992. National Health and Nutrition Examination Survey / JAMA 283:2404~2410
Bos MJ / 2006 / Uric acid is a risk factor for myocardial infarction and stroke: the Rotterdam study / Stroke 37:1503~1507
Casjens S / 2013 / Diagnostic value of the impairment of olfaction in Parkinson's disease / PLoS One 8:e64735
Hughes TA / 2000 / A 10-year study of the incidence of and factors predicting dementia in Parkinson's disease / Neurology 54:1596~1602
Fang J / 2000 / Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971-1992. National Health and Nutrition Examination Survey / JAMA 283:2404~2410
Bos MJ / 2006 / Uric acid is a risk factor for myocardial infarction and stroke: the Rotterdam study / Stroke 37:1503~1507
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Comparative Olfactory Profiles in Parkinson’s Disease and Drug-Induced Parkinsonism
Journal Of Movement Disorders
2024 .01
-
Accuracy of Machine Learning Using the Montreal Cognitive Assessment for the Diagnosis of Cognitive Impairment in Parkinson’s Disease
Journal Of Movement Disorders
2022 .05
-
노인 환자에 있어 주관적 미각장애와 주관적 후각장애의 연관성
대한이비인후-두경부외과학회지
2023 .03
-
후각 장애를 위한 후각 훈련
임상이비인후과
2022 .06
-
Microglial involvement in the development of olfactory dysfunction
Journal of Veterinary Science
2018 .05
-
Association between Serum Uric Acid Level and ESRD or Death in a Korean Population
Journal of Korean Medical Science
2020 .01
-
Clinical Implication of High Sensitivity C-Reactive Protein for the Development of Dementia in Parkinson’s Disease
Dementia and Neurocognitive Disorders(대한치매학회지)
2015 .01
-
한국인 후각장애환자에서 후각훈련과 비강내 스테로이드스프레이의 효과
Journal of Rhinology
2019 .01
-
High serum uric acid within the normal range is a useful predictor of hypertension among Japanese community-dwelling elderly women
Clinical Hypertension
2021 .01
-
Changes in Epidemiological Trends and Rehabilitation Usage in Neurological Diseases in Korea: Parkinson's Disease
뇌신경재활
2021 .01
-
Factors Influencing Cognitive Dysfunction in Korean Patients with Rheumatoid Arthritis
노인간호학회지
2020 .01
-
Can Olfactory Tests Help to Diagnose Parkinson Disease?
Clinical and Experimental Otorhinolaryngology
2019 .01
-
Subjective Cognitive Complaints and Objective Cognitive Impairment in Parkinson’s Disease
Journal of Clinical Neurology
2018 .01
-
Effect of Uric Acid on the Development of Chronic Kidney Disease: The Korean Multi-Rural Communities Cohort Study
예방의학회지
2018 .01
-
Trend of Olfactory and Gustatory Dysfunction in COVID-19 Patients in a Quarantine Facility
Journal of Korean Medical Science
2020 .01
-
Practical Review of Olfactory Training and COVID-19
Journal of Rhinology
2022 .11
-
유방암 환자에서 항암화학요법 후 인지기능과 후각기능의 변화 : 예비연구
생물치료정신의학
2017 .06
-
Serum uric acid to creatinine ratio is a useful predictor of all-cause mortality among hypertensive patients
Clinical Hypertension
2023 .01
-
A review on photobiomodulation therapy for olfactory dysfunction caused by COVID-19
MEDICAL LASERS
2022 .06
-
그룹 전산화 인지 재활 프로그램이 인지 손상 환자의 인지 기능에 미치는 효과
PNF and movement
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0