지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 26 - 29 (4page)
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초록· 키워드
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Langerhans cell histiocytosis (LCH) has diverse clinical manifestations, including intracranial mass lesions. We report a case of LCH that manifested as a suprasellar mass, and initially misdiagnosed as a germ cell tumor. A 29-year-old woman presented with polyuria, polydipsia and amenorrhea. Laboratory findings revealed hypopituitarism with central diabetes insipidus, and a suprasellar mass and a pineal mass were observed on magnetic resonance imaging. Under the clinical impression of a germ cell tumor, the patient was treated with germ cell tumor chemotherapy (cisplatin and etoposide) and radiation therapy without biopsy. After initial shrinkage of the lesions, further growth of the tumor was observed and a biopsy was performed. The histopathology revealed LCH. After chemotherapy according to the LCH III protocol, the tumor disappeared. She is on regular follow up for 5 years without relapse. The present findings indicate that LCH should be included in the differential diagnosis of a suprasellar mass, even in adults, especially when it manifests with diabetes insipidus. This case also underscores the importance of a histopathologic diagnosis in patients with suprasellar tumors before the initiation of a specific therapy, even if the clinical findings are highly suggestive of a specific diagnosis.
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참고문헌 (13)
참고문헌 신청
Hershey BL / 1993 / Suprasellar masses: diagnosis and differential diagnosis / Semin Ultrasound CT MR 14:215~231
Favara BE / 1994 / The histopathology of Langerhans cell histiocytosis / Br J Cancer Suppl 23:S17~S23
Grois N / 2006 / Risk factors for diabetes insipidus in langerhans cell histiocytosis / Pediatr Blood Cancer 46:228~233
Baumgartner I / 1997 / Langerhans’-cell histiocytosis in adults / Med Pediatr Oncol 28:9~14
Vassallo R / 2000 / Pulmonary Langerhans’-cell histiocytosis / N Engl J Med 342:1969~1978
Favara BE / 1994 / The histopathology of Langerhans cell histiocytosis / Br J Cancer Suppl 23:S17~S23
Grois N / 2006 / Risk factors for diabetes insipidus in langerhans cell histiocytosis / Pediatr Blood Cancer 46:228~233
Baumgartner I / 1997 / Langerhans’-cell histiocytosis in adults / Med Pediatr Oncol 28:9~14
Vassallo R / 2000 / Pulmonary Langerhans’-cell histiocytosis / N Engl J Med 342:1969~1978
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