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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 591 - 599 (9page)
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BACKGROUND: The purpose of this study is to examine physical characteristics of and initial biological properties to anodized titanium treated with poly(D,L-lactide-co-glycolide) (PLG) mixed with recombinant human bone morphogenic protein-2 (rhBMP-2). METHODS: Titanium specimens were prepared in groups of four as follows: group NC was anodized under 300 V as control; group PC was anodized then dropped and dried with solution 0.02 ml PLG; group D was anodized then dropped and dried with solution 0.02 ml PLG/rhBMP-2 (3.75 lg per disc); and group E was anodized then coated with 0.02 ml PLG/rhBMP-2 (3.75 lg per disc) by electrospray. Human osteoblastic-like sarcoma cells were cultured. Cell proliferation and alkaline phosphatase (ALP) activity test were carried out. Runx-2 gene was investigated by the reverse transcriptionpolymerase chain reaction. Immunofluorescence outcome of osteogenic proteins was observed. RESULTS: After 3 days, there were significantly higher proliferations compared rhBMP-2 loaded titanium discs with rhBMP-2 unloaded discs. The ALPase activity on rhBMP-2 loaded titanium discs was significantly higher than in rhBMP-2 unloaded discs. The expression level of Runx2 mRNA presented the highest on the PLG/rhBMP-2-coated surface. CONCLUSION: PLG polymers mixed with rhBMP-2 might improve proliferation, differentiation and osteogenic protein formation of cells on the anodized titanium.
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참고문헌 (27)
참고문헌 신청
Le Guehennec L / 2007 / Surface treatments of titanium dental implants for rapid osseointegration / Dent Mater 23:844~854
Puleo DA / 1999 / Understanding and controlling the bone implant interface / Biomaterials 20:2311~2321
Chu TM / 2007 / Segmental bone regeneration using a load-bearing biodegradable carrier of bone morphogenetic protein-2 / Biomaterials 28:459~467
Takuwa Y / 1991 / Bone morphogenetic protein-2 stimulates alkaline phosphatase activity and collagen synthesis in cultured osteoblastic cells, MC3T3-E1 / Biochem Biophys Res Commun 174:96~101
Jones AL / 2006 / Recombinant human BMP-2 and allograft compared with autogenous bone graft for reconstruction of diaphyseal tibial fractures with cortical defects: a randomized controlled trial / J Bone Joint Surg Am 88:1431~1441
Puleo DA / 1999 / Understanding and controlling the bone implant interface / Biomaterials 20:2311~2321
Chu TM / 2007 / Segmental bone regeneration using a load-bearing biodegradable carrier of bone morphogenetic protein-2 / Biomaterials 28:459~467
Takuwa Y / 1991 / Bone morphogenetic protein-2 stimulates alkaline phosphatase activity and collagen synthesis in cultured osteoblastic cells, MC3T3-E1 / Biochem Biophys Res Commun 174:96~101
Jones AL / 2006 / Recombinant human BMP-2 and allograft compared with autogenous bone graft for reconstruction of diaphyseal tibial fractures with cortical defects: a randomized controlled trial / J Bone Joint Surg Am 88:1431~1441
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