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논문 기본 정보

자료유형
학술저널
저자정보
Nasar Um Min Allah (Universiti Sains Malaysia) Zurairah Berahim (Universiti Sains Malaysia) Azlina Ahmad (Universiti Sains Malaysia) Thirumulu Ponnuraj Kannan (Universiti Sains Malaysia)
저널정보
한국조직공학과 재생의학회 조직공학과 재생의학 조직공학과 재생의학 제14권 제5호
발행연도
2017.1
수록면
495 - 505 (11page)

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Advancement in cell culture protocols, multidisciplinary research approach, and the need of clinical implication to reconstruct damaged or diseased tissues has led to the establishment of three-dimensional (3D) test systems for regeneration and repair. Regenerative therapies, including dental tissue engineering, have been pursued as a new prospect to repair and rebuild the diseased/lost oral tissues. Interactions between the different cell types, growth factors, and extracellular matrix components involved in angiogenesis are vital in the mechanisms of new vessel formation for tissue regeneration. In vitro pre-vascularization is one of the leading scopes in the tissue-engineering field. Vascularization strategies that are associated with co-culture systems have proved that there is communication between different cell types with mutual beneficial effects in vascularization and tissue regeneration in two-dimensional or 3D cultures. Endothelial cells with different cell populations, including osteoblasts, smooth muscle cells, and fibroblasts in a co-culture have shown their ability to advocate pre-vascularization. In this review, a co-culture perspective of human gingival fibroblasts and vascular endothelial cells is discussed with the main focus on vascularization and future perspective of this model in regeneration and repair.

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