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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 547 - 553 (7page)
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초록· 키워드
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Hypoxic condition influences biological responses in various cell types. However, a hypoxic regulating osteogenic differentiation remains controversy. Here, an influence of short-term culture in hypoxic condition on osteogenic marker gene expression by retinoic acid-treated murine gingival fibroblast-derived induced pluripotent stem cells (RA-miPS) was investigated. Results demonstrated that hypoxic condition significantly upregulated Vegf, Runx2, Osx, and Ocn mRNA expression by RA-miPS in normal culture medium at day 3. Further, desferrioxamine significantly downregulated pluripotent marker (Nanog and Oct4) and enhanced osteogenic marker (Runx2, Osx, Dlx5, and Ocn) gene expression as well as promoted in vitro mineral deposition. However, the effect of cobalt chloride on osteogenic differentiation of RA-miPS was not robust. In summary, the results imply that hypoxic condition may be useful in the enhancement of osteogenic differentiation in RA-miPS.
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참고문헌 (27)
참고문헌 신청
Hakim F / 2014 / High oxygen condition facilitates the differentiation of mouse and human pluripotent stem cells into pancreatic progenitors and insulin-producing cells / J Biol Chem 289:9623~9638
Medley TL / 2013 / Effect of oxygen on cardiac differentiation in mouse iPS cells: role of hypoxia inducible factor-1 and Wnt/beta-catenin signaling / PLoS One 8:e80280
Iida K / 2013 / Hypoxia-enhanced derivation of iPSCs from human dental pulp cells / J Dent Res 92:905~910
Wion D / 2009 / PO(2)matters in stem cell culture / Cell Stem Cell 5:242~243
Sugimoto K / 2013 / Effects of hypoxia on pluripotency in murine iPS cells / Microsc Res Tech 76:1084~1092
Medley TL / 2013 / Effect of oxygen on cardiac differentiation in mouse iPS cells: role of hypoxia inducible factor-1 and Wnt/beta-catenin signaling / PLoS One 8:e80280
Iida K / 2013 / Hypoxia-enhanced derivation of iPSCs from human dental pulp cells / J Dent Res 92:905~910
Wion D / 2009 / PO(2)matters in stem cell culture / Cell Stem Cell 5:242~243
Sugimoto K / 2013 / Effects of hypoxia on pluripotency in murine iPS cells / Microsc Res Tech 76:1084~1092
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