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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 270 - 273 (4page)
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Regulation of immune cell function is an important in the field of hormone-related tissue engineering and regenerative medicine. In this sense, hormonal regulation of immune cell function is a critical issue to be solved. It has been known that ovarian sex hormone play an important roles in immune function, however, little has been known whether estrogen affects T-lymphocyte function. Human Jurkat T cells were treated with estradiol (E2) at concentrations of 0, 10, 100, 1000 ng/mL, and calcium response was evaluated. Intracellular calcium concentrations after Fura-2 acetoxymethyl ester treatment show an increasing trend at higher E2 concentrations although these alterations did not reach a statistical significance. The expression of calcium channel-related gene CACNA1C did not show any significant changes according to the concentration of E2. Taken together, estrogen has an implication as a possible hormonal regulator of intracellular calcium release in human Jurkat T cells via non-genomic pathway. Further studies are necessary to investigate the combined effects of sex hormones and cytokines in both T- and B-lymphocytes.
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참고문헌 (15)
참고문헌 신청
Fritz MA / 2012 / Clinical Gynecologic Endocrinology and Infertility / Lippincott Williams & Wilkins :45~57
Pernis AB / 2007 / Estrogen and CD4+ T cells / Curr Opin Rheumatol 19:414~420
Straub RH / 2007 / The complex role of estrogens in inflammation / Endocr Rev 28:521~574
Buyon JP / 1998 / The effects of pregnancy on autoimmune diseases / J Leukoc Biol 63:281~287
Shim GJ / 2006 / Differential expression of oestrogen receptors in human secondary lymphoid tissues / J Pathol 208:408~414
Pernis AB / 2007 / Estrogen and CD4+ T cells / Curr Opin Rheumatol 19:414~420
Straub RH / 2007 / The complex role of estrogens in inflammation / Endocr Rev 28:521~574
Buyon JP / 1998 / The effects of pregnancy on autoimmune diseases / J Leukoc Biol 63:281~287
Shim GJ / 2006 / Differential expression of oestrogen receptors in human secondary lymphoid tissues / J Pathol 208:408~414
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