지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 13 - 20 (8page)
이용수
이 논문의 연구 히스토리 (2)
- 이 논문의 후속연구가 궁금하신가요?
- 연관 학술논문 또는 학술발표를 통해 보다 발전된 연구결과를 확인하실 수 있습니다.
- 이 논문의 연구 히스토리 확인하기
초록· 키워드
오류제보하기
Growth factors play multiple and critical roles in wound repair processes. Platelet-derived growth factor (PDGF) is a potent growth factor that is particularly important in the early inflammatory phase of wound healing. In order to extend the half-life of PDGF, polymeric encapsulation is used. In the current study, Poly (lactic-co-glycolic acid) (PLGA) microspheres containing recombinant human (rh) PDGF-BB were prepared to prolong the effectiveness of this growth factor. PLGA microspheres were optimized using a modified w/o/w-double-emulsion/solvent evaporation method by changing the processing conditions of stirring speed and emulsifier (polyvinyl alcohol) concentration. Microspheres prepared using the optimized method released rhPDGF-BB for up to three weeks. An in vitro migration assay showed a significant decrease in the wound area in cells treated with rhPDGF-BB microspheres compared to control cells. These findings demonstrate the potential of rhPDGF-BB encapsulated in microspheres to enhance wound healing.
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Kiritsy CP / 1993 / Lynch SE. Role of growth factors in cutaneous wound healing: a review / Crit Rev Oral Biol Med 4:729~760
Yager DR / 1996 / Wound fluids from human pressure ulcers contain elevated matrix metalloproteinase levels and activity compared to surgical wound fluids / J Invest Dermatol 107:743~748
Bullen EC / 1995 / Tissue inhibitor of metalloproteinases-1 is decreased and activated gelatinases are increased in chronic wounds / J Invest Dermatol 104:236~240
Heldin CH / 1979 / Platelet-derived growth factor:purification and partial characterization / Proc Natl Acad Sci U S A 76:3722~3726
Pierce GF / 1991 / Role of platelet-derived growth factor in wound healing / J Cell Biochem 45:319~326
Yager DR / 1996 / Wound fluids from human pressure ulcers contain elevated matrix metalloproteinase levels and activity compared to surgical wound fluids / J Invest Dermatol 107:743~748
Bullen EC / 1995 / Tissue inhibitor of metalloproteinases-1 is decreased and activated gelatinases are increased in chronic wounds / J Invest Dermatol 104:236~240
Heldin CH / 1979 / Platelet-derived growth factor:purification and partial characterization / Proc Natl Acad Sci U S A 76:3722~3726
Pierce GF / 1991 / Role of platelet-derived growth factor in wound healing / J Cell Biochem 45:319~326
이 논문의 저자 정보
최근 본 자료
댓글(0)
0