지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 147 - 152 (6page)
이용수
초록· 키워드
오류제보하기
The purpose of the present study was to evaluate the correlations between high platelet reactivity (HPR) and the extent of coronary atherosclerosis and periprocedural myonecrosis in patients with acute coronary syndrome (ACS) who underwent percutaneous coronary intervention (PCI). A total of 485 patients who underwent PCI for ACS was studied. HPR was defined as ≥230 platelet reactivity units (PRU) in point-of-care P2Y12 tested by the VerifyNow assay. The incidence of multi-vessel disease (MVD) was higher in patients with HPR than those with no HPR (56.2% vs 45.8%, p=0.023). PRU values progressively increased with the number of diseased coronary arteries (1-vessel disease 221.8±86.7; 2-vessel disease 239.3±90.1; 3-vessel disease 243.4±84.5; p=0.038 by ANOVA). Multivariate analysis revealed that HPR was independently associated with MVD (Odds ratio 1.48, 95% confidence interval 1.01-2.25, p=0.048). Patients with periprocedural myonecrosis showed significantly higher PRU values compared with those without myonecrosis (258.6±94.5 vs. 228.5±85.6, p=0.013). Multivariate analysis revealed that HPR was an independent predictor for periprocedural myonecrosis as defined as any creatine kinase-myocardial band isoenzyme elevation or troponin T elevation. In conclusion, HPR is associated with MVD and periprocedural myonecrosis in patients with ACS and PCI. Thus, platelet reactivity after treatment with clopidogrel might be associated not only with blood clot formation but also with increased coronary atherosclerotic burden.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Aleil B / 2005 / Flow cytometric analysis of intraplatelet VASP phosphorylation for the detection of clopidogrel resistance in patients with ischemic cardiovascular diseases / J Thromb Haemost 3:85~92
Gurbel PA / 2005 / Clopidogrel effect on platelet reactivity in patients with stent thrombosis : results of the CREST Study / J Am Coll Cardiol 46:1827~1832
Matetzky S / 2004 / Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction / Circulation 109:3171~3175
Bliden KP / 2007 / Increased risk in patients with high platelet aggregation receiving chronic clopidogrel therapy undergoing percutaneous coronary intervention: is the current antiplatelet therapy adequate? / J Am Coll Cardiol 49:657~666
Gawaz M / 2008 / Platelets modulate atherogenesis and progression of atherosclerotic plaques via interaction with progenitor and dendritic cells / J Thromb Haemost 6:235~242
Gurbel PA / 2005 / Clopidogrel effect on platelet reactivity in patients with stent thrombosis : results of the CREST Study / J Am Coll Cardiol 46:1827~1832
Matetzky S / 2004 / Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction / Circulation 109:3171~3175
Bliden KP / 2007 / Increased risk in patients with high platelet aggregation receiving chronic clopidogrel therapy undergoing percutaneous coronary intervention: is the current antiplatelet therapy adequate? / J Am Coll Cardiol 49:657~666
Gawaz M / 2008 / Platelets modulate atherogenesis and progression of atherosclerotic plaques via interaction with progenitor and dendritic cells / J Thromb Haemost 6:235~242
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