지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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The gonadotropin-releasing hormone (GnRH) stimulation test is the gold standard fordifferentiating central precocious puberty (CPP) from exaggerated thelarche (ET). Because of this test’s limitations, previous studies have clarified the clinical and laboratoryfactors that predict CPP. The present study investigated the early diagnostic significanceof pelvic ultrasound in girls with CPP. The GnRH stimulation test and pelvicultrasound were performed between March 2007 and February 2015 in 192 girls (aged＜8 years) with signs of early puberty and advanced bone age. Ninety-three of 192 patients(48.4%) were diagnosed as having CPP and the others (51.6%) as having ET. The CPPgroup had higher uterine volumes (4.31±2.79 mL) than did the ET group (3.05±1.97 mL,p=0.03). No significant differences were found in other ultrasonographic parameters. Byuse of receiver operating characteristic curve analysis, the most predictive parameterfor CPP was a uterine volume of least 3.30 mL, with an area under the curve of 0.659(95% confidence interval: 0.576-0.736). The CPP group had significantly higher uterinevolumes than did the ET group, but there were no reliable cutoff values in pelvic ultrasoundfor differentiating between CPP and ET. Pelvic ultrasound should be combinedwith clinical and laboratory tests to maximize its diagnostic value for CPP.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Garibaldi LR / 1993 / The pattern of gonadotropin and estradiol secretion in exaggerated thelarche / Acta Endocrinol 128:345~350
Pescovitz OH / 1988 / Premature thelarche and central precocious puberty: the relationship between clinical presentation and the gonadotropin response to luteinizing hormone-releasing hormone / J Clin Endocrinol Metab 67:474~479
Stanhope R / 2000 / J Pediatr Endocrinol Metab / J Pediatr Endocrinol Metab 13(Suppl 1):827~830
Stanhope R / 1990 / Thelarche variant: a new syndrome of precocious sexual maturation? / Acta Endocrinol 123:481~486
Schwarz HP / 1990 / Unsustained central sexual precocity in four girls / Am J Med Sci 299:260~264
Pescovitz OH / 1988 / Premature thelarche and central precocious puberty: the relationship between clinical presentation and the gonadotropin response to luteinizing hormone-releasing hormone / J Clin Endocrinol Metab 67:474~479
Stanhope R / 2000 / J Pediatr Endocrinol Metab / J Pediatr Endocrinol Metab 13(Suppl 1):827~830
Stanhope R / 1990 / Thelarche variant: a new syndrome of precocious sexual maturation? / Acta Endocrinol 123:481~486
Schwarz HP / 1990 / Unsustained central sexual precocity in four girls / Am J Med Sci 299:260~264
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