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논문 기본 정보

자료유형
학술저널
저자정보
Naoki Minami (Department of Gastroenterology and Hepatology Graduate School of Medicine Kyoto University) Minoru Matsuura (Department of Gastroenterology and Hepatology Graduate School of Medicine Kyoto University) Yorimitsu Koshikawa (Department of Gastroenterology and Hepatology Graduate School of Medicine Kyoto University) Satoshi Yamada (Department of Gastroenterology and Hepatology Graduate School of Medicine Kyoto University) Yusuke Honzawa (Department of Gastroenterology and Hepatology Graduate School of Medicine Kyoto University) Shuji Yamamoto (Department of Gastroenterology and Hepatology Graduate School of Medicine Kyoto University) Hiroshi Nakase (Department of Gastroenterology and Hepatology Sapporo Medical University School of Medicine)
저널정보
대한장연구학회 Intestinal research Intestinal research Vol.15 No.1
발행연도
2017.1
수록면
90 - 96 (7page)

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Background/Aims: Our physicians work to expand the possibilities to treat female patients with inflammatory bowel disease(IBD) who wish to become pregnant. Although many drugs, including 5-aminosalicylate (5-ASA), corticosteroids, immunomodulators,and biologics, are used safely during pregnancy, few reports have described the therapeutic regimen throughoutpregnancy and the management of patients who relapse during pregnancy precisely. The aim of this study was to assess themanagement of patients with IBD during pregnancy. Methods: We identified 19 patients (five with Crohn’s disease and 14with ulcerative colitis [UC]) who became pregnant with a total of 23 pregnancies between May 2005 and May 2015 by reviewingthe medical records of Kyoto University Hospital. The following data were collected: the maternal variables, the IBD treatmenttype, the disease activity, the pregnancy outcome, and the mode of delivery. Results: Among the 19 patients, 18 had becomepregnant after being diagnosed with IBD, while one had developed UC newly after pregnancy. Throughout the gestation,all patients were treated with probiotics, 5-ASA, prednisolone, cytapheresis, or infliximab. The relapse rate during pregnancywas 21.7% (5/23 cases). The five patients who experienced a relapse were able to pursue their pregnancy after intensification oftheir treatments. There were no adverse fetal or neonatal problems, except in one case that required an emergency Caesareansection because of placental dysfunction and in which a very low-birth-weight infant was born preterm. Conclusions: Ourpresent data confirmed that even if the disease flares up during pregnancy, good pregnancy outcomes can be achieved with anoptimal intensification of the patient’s treatment.

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참고문헌 (21)

참고문헌 신청
Abraham C / 2009 / Inflammatory bowel disease / N Engl J Med 361:2066~2078 google schola Loftus EV Jr / 2002 / Epidemiology of inflammatory bowel disease / Gastroenterol Clin North Am 31:1~20 google schola Baumgart DC / 2007 / Inflammatory bowel disease:clinical aspects and established and evolving therapies / Lancet 369:1641~1657 google schola van der Woude CJ / 2015 / The second European evidenced-based consensus on reproduction and pregnancy in inflammatory bowel disease / J Crohns Colitis 9:107~124 google schola Walmsley RS / 1998 / A simple clinical colitis activity index / Gut 43:29~32 google schola

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