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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 75 - 82 (8page)
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Background/Aims: Cyclooxygenase-2 (COX-2), 15-hydroxyprostaglandin dehydrogenase (15-PGDH), and microsomalprostaglandin E synthase-1 (mPGEs-1) regulate prostaglandin E2 (PGE2) expression and are involved in colon carcinogenesis. We investigated the expression of PGE2 and its regulating genes in sporadic human colon tumors and matched normal tissues. Methods: Twenty colonic adenomas and 27 colonic adenocarcinomas were evaluated. COX-2 and 15-PGDH expression wasquantified by real-time polymerase chain reaction. The expression of PGE2 and mPGEs-1 was measured using enzyme-linkedimmunosorbent assay and Western blotting, respectively. Results: The expression of COX-2, mPGEs-1, and PGE2 did not differbetween the adenomas and matched distant normal tissues. 15-PGDH expression was lower in adenomas than in the matchednormal colonic tissues (P <0.001). In adenocarcinomas, mPGEs-1 and PGE2 expression was significantly higher (P <0.001 andP =0.020, respectively), and COX-2 expression did not differ from that in normal tissues (P =0.207). 15-PGDH expression wassignificantly lower in the normal colonic mucosa from adenocarcinoma patients than in the normal mucosa from adenomapatients (P =0.018). Conclusions: Early inactivation of 15-PGDH, followed by activation of COX-2 and mPGEs-1, contributesto PGE2 production, leading to colon carcinogenesis. 15-PGDH might be a novel candidate marker for early detection of fielddefects in colon carcinogenesis.
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참고문헌 (18)
참고문헌 신청
Slaughter DP. / 1953 / The role of internal mammary node dissection in the treatment of breast cancer / Proc Inst Med Chic 19:300
Cheung DY / 2008 / The anatomical distribution of colorectal cancer in Korea: evaluation of the incidence of proximal and distal lesions and synchronous adenomas / Intern Med 47:1649~1654
Shin A / 2011 / Associations of cigarette smoking and alcohol consumption with advanced or multiple colorectal adenoma risks: a colonoscopy-based case-control study in Korea / Am J Epidemiol 174:552~562
Jothy S / 1996 / Field effect of human colon carcinoma on normal mucosa:relevance of carcinoembryonic antigen expression / Tumour Biol 17:58~64
Chen LC / 2004 / Alteration of gene expression in normal-appearing colon mucosa of APC(min) mice and human cancer patients / Cancer Res 64:3694~3700
Cheung DY / 2008 / The anatomical distribution of colorectal cancer in Korea: evaluation of the incidence of proximal and distal lesions and synchronous adenomas / Intern Med 47:1649~1654
Shin A / 2011 / Associations of cigarette smoking and alcohol consumption with advanced or multiple colorectal adenoma risks: a colonoscopy-based case-control study in Korea / Am J Epidemiol 174:552~562
Jothy S / 1996 / Field effect of human colon carcinoma on normal mucosa:relevance of carcinoembryonic antigen expression / Tumour Biol 17:58~64
Chen LC / 2004 / Alteration of gene expression in normal-appearing colon mucosa of APC(min) mice and human cancer patients / Cancer Res 64:3694~3700
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