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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 208 - 215 (8page)
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This study proposes a handheld electronics module integrated with the microchip that utilizes dielectrophoretic (DEP) impedance measurement for characterizing of cancerous cell lines. The microchip consists of circle-on-line-shaped interdigitated microelectrodes, which were used for DEP concentration and impedance sensing of cells within a chamber, patterned by standard microfabrication processes. The handheld electronics module was built for measuring impedance of cancerous cells in the microchip. It can provide sinusoidal electrical signals in a large range of frequencies. The analyzed results demonstrate a high-sensitivity impedance measurement. Meanwhile, the linear relationships between the admittance variation and the number of cell were observed for both two human lung cell lines, namely A549 human lung carcinoma cells and MRC-5 human lung epithelial cells. The difference in the slopes of these characteristic lines could be used to distinguish two stages of lung cells. The proposed device is simple to operate, has high sensitivity, inexpensive and portable.
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참고문헌 (34)
참고문헌 신청
Torre, L.A. / 2015 / Global cancer statistics, 2012 / Ca-Cancer J. Clin. 65:87~108
Shacham-Diamand, Y. / 2010 / Optical and electrical interfacing technologies for living cell bio-chips / Curr. Pharm. Biotechnol. 11:376~383
Stiharu, I. / 2015 / Single living cell manipulation and identification using microsystems technologies / Microsyst. Nanoeng. 1:15031
Xu, Y. / 2016 / A review of impedance measurements of whole cells / Biosens. Bioelectron. 77:824~836
Chuang, C.H. / 2011 / System-level biochip for impedance sensing and programmable manipulation of bladder cancer cells / Sensors 11:11021~11035
Shacham-Diamand, Y. / 2010 / Optical and electrical interfacing technologies for living cell bio-chips / Curr. Pharm. Biotechnol. 11:376~383
Stiharu, I. / 2015 / Single living cell manipulation and identification using microsystems technologies / Microsyst. Nanoeng. 1:15031
Xu, Y. / 2016 / A review of impedance measurements of whole cells / Biosens. Bioelectron. 77:824~836
Chuang, C.H. / 2011 / System-level biochip for impedance sensing and programmable manipulation of bladder cancer cells / Sensors 11:11021~11035
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