지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 150 - 157 (8page)
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초록· 키워드
오류제보하기
Crotonaldehyde (CRA), a reactive α,β-unsaturated aldehyde, is produced by natural and synthetic processes such as incomplete combustion of many compounds and can be found in cigarette smoke. CRA induces the formation of DNA adducts and suppresses the expression of glutathione, resulting in endothelial dysfunction, inflammation and vascular diseases. MicroRNAs (miRNAs) are small, non-coding RNAs that negatively modulate gene expression by targeting mRNAs for translational repression or degradation. They are also important factors involved in cell growth, apoptosis, and proliferation in cardiovascular disease. In this study, to examine the effect of CRA on the expression profiles of miRNAs in human umbilical vein endothelial cells (HUVECs), we performed pair-wise correlation analyses and identified 162 miRNAs with altered expression upon treatment of HUVECs with 10 μM CRA. In addition, we discovered a significant anti-correlation between 55 miRNAs and 11 mRNA. Differentially expressed miRNAs were further validated by Gene Ontology (GO) enrichment analysis. Our results suggest that modified expression of miRNAs caused by CRA treatment is related to endothelial dysfunction and might contribute to further understanding the molecular mechanisms of vascular diseases.
목차
등록된 정보가 없습니다.
참고문헌 (49)
참고문헌 신청
Fernandes, P. H. / 2005 / Mammalian cell mutagenesis of the DNA adducts of vinyl chloride and crotonaldehyde / Environ. Mol. Mutagen 45:455~459
Jha, A.M. / 2006 / In vivo evaluation of induction of abnormal sperm morphology in mice by an unsaturated aldehyde crotonaldehyde / Mutat. Res. 603:159~163
Kozekov, I.D. / 2003 / DNA interchain cross-links formed by acrolein and crotonaldehyde / J. Am. Chem. Soc 125:50~61
Chung, F.L. / 1996 / Lipid peroxidation as a potential endogenous source for the formation of exocyclic DNA adducts / Carcinogenesis 17:2105~2111
Minko, I.G. / 2009 / Chemistry and biology of DNA containing 1,N (2)-deoxyguanosine adducts of the alpha, beta-unsaturated aldehydes acrolein, crotonaldehyde, and 4-hydroxynonenal / Chem. Res. Toxicol 22:759~778
Jha, A.M. / 2006 / In vivo evaluation of induction of abnormal sperm morphology in mice by an unsaturated aldehyde crotonaldehyde / Mutat. Res. 603:159~163
Kozekov, I.D. / 2003 / DNA interchain cross-links formed by acrolein and crotonaldehyde / J. Am. Chem. Soc 125:50~61
Chung, F.L. / 1996 / Lipid peroxidation as a potential endogenous source for the formation of exocyclic DNA adducts / Carcinogenesis 17:2105~2111
Minko, I.G. / 2009 / Chemistry and biology of DNA containing 1,N (2)-deoxyguanosine adducts of the alpha, beta-unsaturated aldehydes acrolein, crotonaldehyde, and 4-hydroxynonenal / Chem. Res. Toxicol 22:759~778
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