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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 140 - 149 (10page)
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초록· 키워드
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Copper oxide nanoparticles (CuO NPs) are one of the most toxic metal oxide nanoparticles, but they have a wide range of applications in the manufac- ture of industrial and consumer products. While their beneficial aspects are widely acknowledged, the toxic effects of CuO NPs and Cu ions on the neuronal sys- tem may limit their use. Here, we propose a molecular mechanism underlying the response of human neuro- blastoma SH-SY5Y cells to CuO NP and Cu ion expo- sure based on cDNA microarray data. SH-SY5Y cells exposed to CuO NPs and CuCl 2 for 24 hours showed concentration-dependent cell death with similar IC50 values. The expression level of up-regulated genes in CuCl 2 -exposed cells was significantly higher than in CuO NP-exposed cells. CuO NP-exposed cells ar- rested the cell cycle in the G1/S/G2/M phases as a re- sult of an up-regulation of INK4d, CYCE, RB, CDC6, CDC45, GADD45, and BUB1, while CuCl 2 -exposed cells mostly arrested the cell cycle in the G2/M phases as a result of CYCA, CYCB, CDK1, CDC20, PIK1, and BUB1 up-regulation. Our results suggest that the IC50 value had no significant relation with gene expression changes because the gene expression study may be in part due to cytotoxic mechanisms.
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참고문헌 (30)
참고문헌 신청
Pal, J. / 2015 / Faceted metal and metal oxide nanoparticles: design, fabrication and catalysis / Nanoscale 7:14159~14190
Sun, Y.F. / 2012 / Metal oxide nanostructures and their gas sensing properties: A review / Sensors 12:2610~2631
Badawy, W.A. / 2015 / A review on solar cells from Sisingle crystals to porous materials and quantum dots / J. Adv. Res 6:123~132
Kidowaki, H. / 2012 / Fabrication and characterization of CuO-based solar cells / J. Mat. Sci. Res 1:138~143
Gupta, K. / 2010 / Synthesis of La 0.67 Sr 0.33 MnO 3 and polyaniline nanocomposite with its electrical and magneto-transport properties / J. Appl. Phys 107:073704
Sun, Y.F. / 2012 / Metal oxide nanostructures and their gas sensing properties: A review / Sensors 12:2610~2631
Badawy, W.A. / 2015 / A review on solar cells from Sisingle crystals to porous materials and quantum dots / J. Adv. Res 6:123~132
Kidowaki, H. / 2012 / Fabrication and characterization of CuO-based solar cells / J. Mat. Sci. Res 1:138~143
Gupta, K. / 2010 / Synthesis of La 0.67 Sr 0.33 MnO 3 and polyaniline nanocomposite with its electrical and magneto-transport properties / J. Appl. Phys 107:073704
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