Planar Biochip System for Combinatorial Electrokinetics

Rajeshwari Taruvai Kalyana Kumar; Kavya Cherukuri; Ridhima Chadha; Victoria Holderby; Shalini Prasad

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저자정보: Rajeshwari Taruvai Kalyana Kumar (University of Texas at Dallas) Kavya Cherukuri (University of Texas at Dallas) Ridhima Chadha (University of Texas at Dallas) Victoria Holderby (University of Texas at Dallas) Shalini Prasad (University of Texas at Dallas)

저널정보: 한국바이오칩학회 BioChip Journal BioChip Journal Vol.10 No.2

발행연도: 2016.1

수록면: 131 - 139 (9page)

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This study presents a methodology of in- tegrating dielectrophoresis (DEP) and electrorotation (ROT) on to a planar open electrode system platform to combinatorially characterize and separate organic and inorganic micro particles separate We have optimized methods to develop “biochip” prototype device that is easy to fabricate with an electrode geometry that en- ables unique combination of programmed input electri- cal signals that induces DEP and ROT simultaneously for micro-particle separation. We have demonstrated the isolation of target organic/inorganic particles from a heterogeneous sample population using dynamic DEP and ROT induced electric fields. Target particles were effectively separated and simultaneously analyzed for its dielectric properties using dynamic electrode geo- metry. In this study we have successfully shown the separation of two study models with separation effi- ciency of > 96% from heterogeneous mixture of orga- nic (HeLa and HEK cells) and inorganic (polystyrene beads) particles as a proof-of-feasibility suitable for translation research.

참고문헌 (27)

참고문헌 신청

Dittrich, P.S. / 2006 / Lab-on-a-chip: microfluidics in drug discovery / Nat Rev Drug Discov 5:210~218

Fan, X. / 2011 / Optofluidic microsystems for chemical and biological analysis / Nat Photonics 5:591~597

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Peters, A. / 2009 / High-throughput and combinatorial technologies for tissue engineering applications / Tissue Eng Part B: Rev 15:225~239

Abraham, V. C. / 2004 / High content screening applied to large-scale cell biology / Trends in Biotechnology 22:15~22

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