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Nitric oxide (NO) in general plays a beneficial physiological role as a vasorelaxant and the role of NO is decided by its concentration present in physiological environments. NO either facilitates cancer-promoting characters or act as an anti-cancer agent. The dilemma in this regard still remains unanswered. This review summarizes the recent information on NO and its role in carcinogenesis and tumor progression, as well as dietary chemopreventive agents which have NO-modulating properties with safe cytotoxic profile. Understanding the molecular mechanisms and cross-talk modulating NO effect by these chemopreventive agents can allow us to develop better therapeutic strategies for cancer treatment.
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참고문헌 (94)
참고문헌 신청
Vannini F / 2015 / The dual role of iNOS in cancer / Redox Bio 6:334~343
Fukumura D / 2006 / The role of nitric oxide in tumour progression / Nat Rev Cancer 6:521~534
Burke AJ / 2013 / The yin and yang of nitric oxide in cancer progression / Carcinogenesis 34:503~512
Choudhari SK / 2013 / Nitric oxide and cancer: a review / World J Surg Oncol 11:118
Lee SY / 2014 / A novel liposomal nanomedicine for nitric oxide delivery and breast cancer treatment / Biomed Mater Eng 24:61~67
Fukumura D / 2006 / The role of nitric oxide in tumour progression / Nat Rev Cancer 6:521~534
Burke AJ / 2013 / The yin and yang of nitric oxide in cancer progression / Carcinogenesis 34:503~512
Choudhari SK / 2013 / Nitric oxide and cancer: a review / World J Surg Oncol 11:118
Lee SY / 2014 / A novel liposomal nanomedicine for nitric oxide delivery and breast cancer treatment / Biomed Mater Eng 24:61~67
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