지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1 - 8 (8page)
이용수
초록· 키워드
오류제보하기
Objective: In the treatment of metastatic soft tissue sarcoma (STS), pazopanib is considered a standard treatment after failure of chemotherapy. We retrospectively investigated outcomes of pazopanib in patients with metastatic uterine STS. Methods: A retrospective study was performed on 35 consecutive patients with uterine STS treated with oral pazopanib 800 mg daily as salvage therapy for metastatic disease between September 2013 and December 2015. Endpoints included response rate, survival, and safety. Results: Among 35 patients, 27 (77%) had a histologic diagnosis of leiomyosarcoma (LMS) and the median age was 57 years (range, 36–70). Median number of metastatic sites was one (range, 1–5) with lung as the most frequently involved site. Pazopanib was generally well-tolerated: the major hematologic toxicity was grade 1/2 anemia (14%). Among the non-hematologic toxicities, grade 1/2 stomatitis was most commonly observed (22%), followed by fatigue and hypertension. Objective response and stable disease were observed in 10 (29%) and 11 (31%) patients, respectively. However, most cases of clinical response were observed in patients with LMS: 33% for LMS, 20% for undifferentiated pleomorphic sarcoma, and 0% for endometrial stromal sarcoma. Median progression-free and overall survivals were 5.8 months (95% confidence interval [CI]=3.6–8.1) and 20.0 months (95% CI=11.6–28.4), respectively. Conclusion: In this “real-world” retrospective study, salvage therapy with pazopanib demonstrated clinically relevant efficacy and tolerability in unselected patients with uterine STS. Although it is encouraging that outcomes for Korean patients with uterine STS were similar to those reported in the phase III trial, the clinical benefit was limited to LMS.
목차
등록된 정보가 없습니다.
참고문헌 (10)
참고문헌 신청
Kummar S / 2013 / Cediranib for metastatic alveolar soft part sarcoma / J Clin Oncol 31:2296~2302
Sleijfer S / 2009 / Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: a phase II study from the European Organisation for Research and Treatment of Cancer-soft Tissue and Bone Sarcoma Group (EORTC Study 62043) / J Clin Oncol 27:3126~3132
Lorigan P / 2007 / Phase III trial of two investigational schedules of ifosfamide compared with standard-dose doxorubicin in advanced or metastatic soft tissue sarcoma: a European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group Study / J Clin Oncol 25:3144~3150
van der Graaf WT / 2012 / Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial / Lancet 379:1879~1886
Yoo KH / 2015 / Efficacy of pazopanib monotherapy in patients who had been heavily pretreated for metastatic soft tissue sarcoma: a retrospective case series / BMC Cancer 15:154
Sleijfer S / 2009 / Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: a phase II study from the European Organisation for Research and Treatment of Cancer-soft Tissue and Bone Sarcoma Group (EORTC Study 62043) / J Clin Oncol 27:3126~3132
Lorigan P / 2007 / Phase III trial of two investigational schedules of ifosfamide compared with standard-dose doxorubicin in advanced or metastatic soft tissue sarcoma: a European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group Study / J Clin Oncol 25:3144~3150
van der Graaf WT / 2012 / Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial / Lancet 379:1879~1886
Yoo KH / 2015 / Efficacy of pazopanib monotherapy in patients who had been heavily pretreated for metastatic soft tissue sarcoma: a retrospective case series / BMC Cancer 15:154
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Uterine Sarcoma: Clinical Presentation, Treatment and Survival Outcomes in Thailand
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Real-World Effectiveness of Pazopanib on Advanced Synovial Sarcoma: Meta-Analysis
보건의료기술평가
2023 .06
-
Primary sarcoma of the cervix: an analysis of patient and tumor characteristics, treatment patterns, and outcomes
Journal of Gynecologic Oncology
2020 .01
-
Sonographic and Clinical Characteristics of Uterine Sarcoma Initially Misdiagnosed as Uterine Fibroid in Women in the Late Reproductive Age
대한폐경학회지
2019 .01
-
Comprehensive Molecular Characterization of Soft Tissue Sarcoma for Prediction of Pazopanib-Based Treatment Response
Cancer Research and Treatment
2023 .04
-
Cutaneous Metastatic Undifferentiated Pleomorphic Sarcoma from a Mediastinal Sarcoma
Annals of Dermatology
2015 .01
-
혈액투석 환자에서 발생한 카포시육종의 Pazopanib 치료 증례
대한내과학회지
2015 .01
-
Outcome analysis in patients with uterine sarcoma
Radiation oncology journal : ROJ
2015 .01
-
Pazopanib as a second line treatment for uterine and ovarian carcinosarcoma: a single institutional study
Journal of Gynecologic Oncology
2017 .01
-
Pazopanib for Non-small Cell Lung Cancer: The First Case Report in Korea
Cancer Research and Treatment
2016 .01
-
Radiation therapy of sarcoma
대한임상종양학회 학술대회지
2020 .07
-
Undifferentiated pleomorphic sarcoma of ascending colon : case report
대한외과학회 학술대회 초록집
2017 .11
-
Sarcoma metastasis to the pancreas: experience at a single institution
Journal of Pathology and Translational Medicine
2020 .01
-
Distribution and survival of primary sarcoma in Korea : A single center analysis of 2017 cases
KOREAN JOURNAL OF CLINICAL ONCOLOGY
2018 .06
-
Real-World Clinical Outcomes and Prognostic Factors for Patients with Advanced Angiosarcoma who Received Systemic Treatment
Cancer Research and Treatment
2021 .10
-
Radiation-Induced Sarcoma: A 15-Year Experience in a Single Large Tertiary Referral Center
Cancer Research and Treatment
2016 .01
-
구개편도에서 발생한 미분화성 다형성 육종 1예
임상이비인후과
2024 .09
-
Intraduodenal undifferentiated pleomorphic sarcoma : A case report
대한외과학회 학술대회 초록집
2019 .10
-
Gastric Undifferentiated Pleomorphic Sarcoma Presenting as a Rapidly Growing Subepithelial Tumor
Korean Journal of Helicobacter Upper Gastrointestinal Research
2024 .09
-
The automatic diagnosis artificial intelligence system for preoperative magnetic resonance imaging of uterine sarcoma
Journal of Gynecologic Oncology
2024 .05
이 논문의 저자 정보
최근 본 자료
댓글(0)
0