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논문 기본 정보

자료유형
학술저널
저자정보
Ming Yin Lin (The University of Queensland School of Medicine) Srinivas Kondalsamy-Chennakesavan (Division of Radiation Oncology) David Bernshaw (Division of Radiation Oncology) Pearly Khaw (University of Melbourne) Kailash Narayan
저널정보
대한부인종양학회 Journal of Gynecologic Oncology Journal of Gynecologic Oncology Vol.27 No.6
발행연도
2016.1
수록면
1 - 11 (11page)

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Objective: The aim of this analysis was to examine the management of cervix cancer inelderly patients referred for radiotherapy and the results of treatment in terms of overallsurvival (OS), relapse-free survival (RFS), and treatment-related toxicities. Methods: Patients were eligible if they were aged ≥75 years, newly diagnosed with cervixcancer and referred for radiotherapy as part of their treatment. Patient details were retrievedfrom the gynaecology service database where clinical, histopathological treatment andfollow-up data were prospectively collected. Results: From 1998 to 2010, 126 patients aged ≥75 years, met selection criteria. Medianage was 81.5 years. Eighty-one patients had definitive radiotherapy, 10 received adjuvantradiotherapy and 35 had palliative radiotherapy. Seventy-one percent of patients had theInternational Federation of Gynecology and Obstetrics stage 1b–2b disease. Median followupwas 37 months. OS and RFS at 3 years among those treated with curative intent were66.6% and 75.9% respectively with majority of patients dying without any evidence of cervixcancer. Grade 2 or more late toxicities were: bladder 5%, bowel 11%, and vagina 27%. EasternCooperative Oncology Group (ECOG) status was a significant predictor of OS and RFS witheach unit increment in ECOG score increased the risk of death by 1.69 times (p<0.001). Conclusion: Following appropriate patient selection, elderly patients treated curativelywith radiotherapy for cervix cancer have good disease control. Palliative hypofractionatedregimens are well tolerated in patients unsuitable for radical treatment.

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참고문헌 (30)

참고문헌 신청
Kamangar F / 2006 / Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world / J Clin Oncol 24:2137~2150 google schola Morris M / 1999 / Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer / N Engl J Med 340:1137~1143 google schola Keys HM / 2004 / A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study / Gynecol Oncol 92:744~751 google schola Narayan K / 2009 / Patterns of failure and prognostic factor analyses in locally advanced cervical cancer patients staged by positron emission tomography and treated with curative intent / Int J Gynecol Cancer 19:912~918 google schola Ikeda H / 1999 / Analysis of 57 nonagenarian cancer patients treated by radical radiotherapy: a survey of eight institutions / Jpn J Clin Oncol 29:378~381 google schola

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