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Inflammation, Impaired Motility, and Permeability in a Guinea Pig Model of Postoperative Ileus
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논문 기본 정보

Type
Academic journal
Author
Yoo Jin Lee (Department of Internal Medicine Keimyung University School of Medicine Daegu Korea) Zahid Hussain (Department of Internal Medicine Gangnam Severance Hospital Yonsei University College of Medicine Se) Cheal Wung Huh (Department of Internal Medicine Gangnam Severance Hospital Yonsei University College of Medicine Se)
Journal
Korean Society of Neurogastroenterology and Motility Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.24 No.1 KCI Accredited Journals
Published
2018.1
Pages
147 - 158 (12page)

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Inflammation, Impaired Motility, and Permeability in a Guinea Pig Model of Postoperative Ileus
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Background/Aims Postoperative ileus (POI) is characterized by impaired propulsive function of the gastrointestinal tract after surgery. Although inflammation is considered to be an important pathogenesis of POI, significant data are lacking. We aim to correlate the recovery time of postoperative dysmotility with that of inflammation and mucosal permeability. Methods An experimental POI model of guinea pig was used. Contractile activity of the circular muscle of the stomach, jejunum, ileum, and proximal colon was measured through a tissue bath study. Inflammatory cells were counted, and the expression of calprotectin and tryptase were analyzed. The expression of protease-activated receptor 2 (PAR-2), claudin-1, and claudin-2 were analyzed with immunofluorescence. Results The small bowel and colon showed decreased contractile amplitude in the POI groups compared to control. In contrast to the colon, the contractile amplitude of the small bowel significantly recovered in the POI group at 6 hours after the operation compared to the control group. Inflammation was highly significant in the POI groups compared to the control and sham groups, especially in the colon. Immunofluorescence showed increased PAR-2 expression in the POI groups compared to sham. The decreased claudin-1 expression and increased claudin-2 expression may suggest increased mucosal permeability of the small bowel and colon in the POI groups. Conclusions Increased inflammation and mucosal permeability may play an important role in the differential recovery stages in POI. These data may provide further insights into the pathophysiology and potential new therapeutic prospects of POI.

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References (35)

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Delaney CP / 2006 / On behalf of the Postoperative Ileus Management Council (PIMC). Postoperative ileus: profiles, risk factors and definitions--a framework for optimizing surgical outcomes in patients undergoing major abdominal and colorectal surgery. Clinical consensus update in general surgery google schola Collins TC / 1999 / Risk factors for prolonged length of stay after major elective surgery / Ann Surg 230:251~259 Crossref Finan MA / 1995 / Ileus following gynecologic surgery: management with water-soluble hyperosmolar radiocontrast material / South Med J 88:539~542 Crossref Boeckxstaens GE / 2009 / Neuroimmune mechanisms in postoperative ileus / Gut 58:1300~1311 Crossref Iyer S / 2009 / Economic burden of postoperative ileus associated with colectomy in the United States / J Manag Care Pharm 15:485~494 google schola

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