지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.23 No.3
- 발행연도
- 2017.1
- 수록면
- 349 - 362 (14page)
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초록· 키워드
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Background/Aims: Irritable bowel syndrome (IBS) patients commonly experience psychiatric disorders, such as depression and anxiety. This meta-analysis sought to compare depression and anxiety levels between IBS patients and healthy controls. Methods: We searched major electronic databases (PubMed, EMBASE, MEDLINE, and Cochrane library) to find comparative studies on IBS patients and healthy controls. The primary outcome was a standardized mean difference (SMD) of anxiety and depression levels; sub-group analyses were conducted according to IBS-subtypes. Results: In total, 2293 IBS patients and 4951 healthy controls from 27 studies were included. In random effect analysis, depression and anxiety levels were significantly higher in IBS patients (pooled SMD = 0.76; 95% CI, 0.62–0.90; P < 0.001; I2 = 77.2% and pooled SMD = 0.84; 95% CI, 0.67–1.01; P < 0.001; I2 = 85.6%, respectively). Both analyses’ funnel plots showed symmetry. In meta-regression analysis, heterogeneity was due to the studied region and questionnaire type for both depression and anxiety. In sub-group analyses of IBS-subtype, the pooled SMDs of depression and anxiety levels (IBS with predominant constipation: 0.83 and 0.81, IBS with predominant diarrhea: 0.73 and 0.65, and IBS with mixed bowel habits: 0.62 and 0.75; P < 0.001, respectively) were significantly higher in all IBS-subtypes. Conclusions: The present meta-analysis showed depression and anxiety levels to be higher in IBS patients than in healthy controls, regardless of IBS-subtype. However, the gender effect on psychological factors among IBS patients could not be determined and should be evaluated in prospective studies.
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참고문헌 (75)
참고문헌 신청
Drossman DA / 2016 / Functional gastrointestinal disorders: history, pathophysiology, clinical features and Rome IV / Gastroenterology 150:1262~1279.e2
Lovell RM / 2012 / Global prevalence of and risk factors for irritable bowel syndrome: a meta-analysis / Clin Gastroenterol Hepatol 10:712~721.e4
Mearin F / 2016 / Bowel disorders / Gastroenterology 150:1393~1407.e1395
Van Oudenhove L / 2016 / Biopsychosocial aspects of functional gastrointestinal disorders: how central and environmental processes contribute to the development and expression of functional gastrointestinal disorders / Gastroenterology 150:1355~1367.e2
이상표 / 2015 / The Effect of Emotional Stress and Depression on the Prevalence of Digestive Diseases / Journal of Neurogastroenterology and Motility (JNM) 21(2):273~282
Lovell RM / 2012 / Global prevalence of and risk factors for irritable bowel syndrome: a meta-analysis / Clin Gastroenterol Hepatol 10:712~721.e4
Mearin F / 2016 / Bowel disorders / Gastroenterology 150:1393~1407.e1395
Van Oudenhove L / 2016 / Biopsychosocial aspects of functional gastrointestinal disorders: how central and environmental processes contribute to the development and expression of functional gastrointestinal disorders / Gastroenterology 150:1355~1367.e2
이상표 / 2015 / The Effect of Emotional Stress and Depression on the Prevalence of Digestive Diseases / Journal of Neurogastroenterology and Motility (JNM) 21(2):273~282
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