지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.23 No.1
- 발행연도
- 2017.1
- 수록면
- 109 - 116 (8page)
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초록· 키워드
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Background/Aims: Post-operative ileus (POI) is a common complication of abdominal surgery. DA-9701, an extract of Pharbitis Semen and Corydalis Tuber, is a new prokinetic agent that also alleviates visceral pain. The aim of this study was to investigate whether DA-9701 can ameliorate POI in rats. Methods: A total of 32 rats were divided into 4 groups: no surgery/no medication (NSNM), no surgery/medication (NSM), surgery/no medication (SNM), and surgery/medication (SM). Gastrointestinal transit (GIT), which is assessed by migration of charcoal, and cumulative stool weight were measured at 24 hours after surgery. Results: GIT was significantly more delayed in the SNM group than in the other groups (SNM vs NSNM, P < 0.001; SNM vs NSM, P < 0.001; SNM vs SM, P = 0.005). Cumulative stool weight in that group was also lower than in the no surgery groups (SNM vs NSNM, P = 0.007; SNM vs NSM, P = 0.033), and there was no significant difference between the SM group and the no surgery groups (SM vs NSM, P = 0.703; SM vs NSNM, P = 0.347). Conclusion: DA-9701 can ameliorate POI by reducing delayed GIT and improving defecation in a rat model of POI.
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참고문헌 (35)
참고문헌 신청
Doorly MG / 2012 / Pathogenesis and clinical and economic consequences of postoperative ileus / Surg Clin North Am 92:259~272
Chapelle SL / 2013 / Visceral massage reduces postoperative ileus in a rat model / J Bodyw Mov Ther 17:83~88
Vather R / 2013 / Defining postoperative ileus : results of a systematic review and global survey / J Gastrointest Surg 17:962~972
최석 / 2009 / Induction of Pacemaker Currents by DA-9701, a Prokinetic Agent, in Interstitial Cells of Cajal from Murine Small Intestine / Molecules and Cells 27(3):307~312
Lee TH / 2008 / Gastroprokinetic effects of DA-9701, a new prokinetic agent formulated with Pharbitis Semen and Corydalis Tuber / Phytomedicine 15:836~843
Chapelle SL / 2013 / Visceral massage reduces postoperative ileus in a rat model / J Bodyw Mov Ther 17:83~88
Vather R / 2013 / Defining postoperative ileus : results of a systematic review and global survey / J Gastrointest Surg 17:962~972
최석 / 2009 / Induction of Pacemaker Currents by DA-9701, a Prokinetic Agent, in Interstitial Cells of Cajal from Murine Small Intestine / Molecules and Cells 27(3):307~312
Lee TH / 2008 / Gastroprokinetic effects of DA-9701, a new prokinetic agent formulated with Pharbitis Semen and Corydalis Tuber / Phytomedicine 15:836~843
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