지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
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- 학술저널
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- 대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.23 No.1
- 발행연도
- 2017.1
- 수록면
- 41 - 48 (8page)
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Background/Aims: Gastroesophageal reflux disease (GERD) is one of the main causes of chronic cough. We evaluated the role of microaspiration in the pathogenesis of reflux-related cough by determining the amount of lipid-laden macrophages (LLMs) in bronchoalveolar lavage (BAL) specimens. Methods: A total of 161 cases of chronic cough were evaluated, and 36 patients (average age 48.2 years) were recruited for this single center prospective study. Patients with a history of smoking, angiotensin converting enzyme inhibitor usage, any abnormality on pulmonary function tests, abnormal chest X-rays, occupational or environmental exposures, or upper airway cough syndrome were excluded. GERD was evaluated by 24-hour esophageal impedance-pH monitoring. BAL specimens for LLM determination were obtained from 34 patients by flexible bronchoscopy. Results: Patients with pathological intra-esophageal reflux according to multichannel intraluminal impedance and pH monitoring had higher LLM positivity in BAL specimens than patients without pathological reflux (8/14 in reflux positive group vs 1/22 in reflux negative group; P = 0.004). The BAL cell distribution was not different between the 2 groups (P = 0.574 for macrophages, P = 0.348 for lymphocytes, P = 0.873 for neutrophils and P = 0.450 for eosinophils). Conclusions: Our results confirm the role of the microaspiration of refluxate in the pathogenetic mechanism of chronic cough. While bronchoscopy is indicated in patients with chronic cough, in addition to the routine airway evaluation, BAL and LLM detection should be performed. LLM can be used to diagnose aspiration in reflux-related chronic cough. Future studies are needed to evaluate the response to anti-reflux medications or surgery in patients with LLM positivity.
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참고문헌 (33)
참고문헌 신청
Bonatti H / 2008 / Impact of changing epidemiology of gastroesophageal reflux disease on its diagnosis and treatment / J Gastrointest Surg 12:373~381
Bor S / 2005 / Gastroesophageal reflux disease in a low-income region in Turkey / Am J Gastroenterol 100:759~765
Bor S / 2006 / The prevalence of gastroesophageal reflux disease in Turkey: lessons from a high Helicobacter pylori prevalent country / J Clin Gastroenterol 40:S182~S183
Mungan Z / 2012 / Prevalence and demographic determinants of gastroesophageal reflux disease (GERD) in the Turkish general population. population:a population-based cross-sectional study / Turk J Gastroenterol 23:323~332
Palombini BC / 1999 / A pathogenic triad in chronic cough: asthma, postnasal drip syndrome, and gastroesophageal reflux disease / Chest 116:279~284
Bor S / 2005 / Gastroesophageal reflux disease in a low-income region in Turkey / Am J Gastroenterol 100:759~765
Bor S / 2006 / The prevalence of gastroesophageal reflux disease in Turkey: lessons from a high Helicobacter pylori prevalent country / J Clin Gastroenterol 40:S182~S183
Mungan Z / 2012 / Prevalence and demographic determinants of gastroesophageal reflux disease (GERD) in the Turkish general population. population:a population-based cross-sectional study / Turk J Gastroenterol 23:323~332
Palombini BC / 1999 / A pathogenic triad in chronic cough: asthma, postnasal drip syndrome, and gastroesophageal reflux disease / Chest 116:279~284
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