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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 21 - 26 (6page)
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One of the major pathophysiological features of primary hypertension is an inappropriate activation of the sympathetic nervous system, which is mediated by excessive synthesis and secretion of catecholamine into the blood. Tyrosine hydroxylase(TH), a rate-limiting enzyme in the synthesis of catecholamine, has been highlighted because genetic variations of TH could alter the activity of the sympathetic nervous system activity and subsequently contribute to the pathogenesis of hypertension. Here, we discuss the role of TH as a regulator of sympathetic activity and review several studies that investigated the relationship between genetic variations of TH and hypertension.
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참고문헌 (36)
참고문헌 신청
Luft, FC / 2002 / Hypertension as a complex genetic trait / Semin Nephrol 22:115~126
Croft, JB / 1986 / Transitions of cardiovascular risk from adolescence to young adulthood--the Bogalusa Heart Study: I. Effects of alterations in lifestyle / J Chronic Dis 39:81~90
Hunt, SC / 1989 / Genetic heritability and common environmental components of resting and stressed blood pressures, lipids, and body mass index in Utah pedigrees and twins / Am J Epidemiol 129:625~638
Williams, RR / 1991 / Genetic traits related to hypertension and electrolyte metabolism / Hypertension 17:69~73
Harrap, SB / 1994 / Hypertension: genes versus environment / Lancet 344:169~171
Croft, JB / 1986 / Transitions of cardiovascular risk from adolescence to young adulthood--the Bogalusa Heart Study: I. Effects of alterations in lifestyle / J Chronic Dis 39:81~90
Hunt, SC / 1989 / Genetic heritability and common environmental components of resting and stressed blood pressures, lipids, and body mass index in Utah pedigrees and twins / Am J Epidemiol 129:625~638
Williams, RR / 1991 / Genetic traits related to hypertension and electrolyte metabolism / Hypertension 17:69~73
Harrap, SB / 1994 / Hypertension: genes versus environment / Lancet 344:169~171
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