지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objective：To explore the effect of vascular risk factors to the depressive symptom in Alzheimer’s disease (AD). Methods：Retrospective chart reviews were performed for the patients, who underwent comprehensive neuropsychiatric assessment in the geriatric psychiatric clinic in the period between May of 2015 and January of 2017. Patients with moderate to severe stage of AD, neurological comorbidities and major psychiatric disorders were excluded to minimize the confounding factors. Sixty five newly diagnosed early AD patients were included and bisected by the cutoff point of 5 in the short version of the Geriatric Depression Scale. Comparisons were done between two groups for vascular risk factors and other relevant clinic-demographic variables. Binary logistic regression analysis was additionally performed to estimate the effect of hypertension to the depressive symptoms. Results：Among the investigated vascular risk factors, hypertension was associated with depressive symptom in the early AD patients. In the logistic regression, odd ratio of hypertension for depression was 4.34 (95% confidence interval 1.47-12.79). Conclusion：Depressive symptoms in the AD patients were associated with hypertension. Therefore, managing this vascular factor in the middle age may not only decrease the risk for neurovascular disorders, but also provide additional benefits in curtailing depression in AD.
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참고문헌 (18)
참고문헌 신청
You Joung Kim / 2014 / Prevalence and Trends of Dementia in Korea: A Systematic Review and Meta-Analysis / Journal of Korean Medical Science 29(7):903~912
Kim KW / 2011 / A nationwide survey on the prevalence of dementia and mild cognitive impairment in South Korea / J Alzheimers Dis 23:281~291
오병훈 / 2009 / 치매의 행동•정신 증상 진단 및 관리 / 대한의사협회지 52(11):1048~1054
김태유 / 2004 / 알쯔하이머병의 진행 정동에 따른 행동심리적 증상의 변화 / 대한신경과학회지 22(1):34~39
Tsuno N / 2009 / What is the association between depression and Alzheimer’s disease? / Expert Rev Neurother 9:1667~1676
Kim KW / 2011 / A nationwide survey on the prevalence of dementia and mild cognitive impairment in South Korea / J Alzheimers Dis 23:281~291
오병훈 / 2009 / 치매의 행동•정신 증상 진단 및 관리 / 대한의사협회지 52(11):1048~1054
김태유 / 2004 / 알쯔하이머병의 진행 정동에 따른 행동심리적 증상의 변화 / 대한신경과학회지 22(1):34~39
Tsuno N / 2009 / What is the association between depression and Alzheimer’s disease? / Expert Rev Neurother 9:1667~1676
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