지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 113 - 121 (9page)
이용수
초록· 키워드
오류제보하기
Bestrophin-1 (Best1) is a calcium-activated anion channel identified from retinal pigment epithelium where human mutations are associated with Best’s macular degeneration. Best1 is known to be expressed in a variety of tissues including the brain, and is thought to be involved in many physiological processes. This review focuses on the current state of knowledge on aspects of expression and function of Best1 in the brain. Best1 protein is observed in cortical and hippocampal astrocytes, in cerebellar Bergmann glia and lamellar astrocytes, in thalamic reticular neurons, in meninges and in the epithelial cells of the choroid plexus. The most prominent feature of Best1 is its significant permeability to glutamate and GABA in addition to chloride ions because glutamate and GABA are important transmitters in the brain. Under physiological conditions, both Best1-mediated glutamate release and tonic GABA release from astrocytes modulate neuronal excitability, synaptic transmission and synaptic plasticity. Under pathological conditions such as neuroinflammation and neurodegeneration, reactive astrocytes phenotypically switch from GABA-negative to GABA-producing and redistribute Best1 from the perisynaptic microdomains to the soma and processes to tonically release GABA via Best1. This implicates that tonic GABA release from reactive astrocyte via redistributed Best1 is a common phenomenon that occur in various pathological conditions with astrogliosis such as traumatic brain injury, neuroinflammation, neurodegeneration, and hypoxic and ischemic insults. These properties of Best1, including the permeation and release of glutamate and GABA and its redistribution in reactive astrocytes, promise us exciting discoveries of novel brain functions to be uncovered in the future.
목차
등록된 정보가 없습니다.
참고문헌 (42)
참고문헌 신청
Marquardt A / 1998 / Mutations in a novel gene, VMD2, encoding a protein of unknown properties cause juvenile-onset vitelliform macular dystrophy (Best’s disease) / Hum Mol Genet 7:1517~1525
Petrukhin K / 1998 / Identification of the gene responsible for Best macular dystrophy / Nat Genet 19:241~247
Eggermont J / 2004 / Calcium-activated chloride channels:(un)known, (un)loved? / Proc Am Thorac Soc 1:22~27
Kunzelmann K / 2007 / Calcium-dependent chloride conductance in epithelia: is there a contribution by bestrophin? / Pflugers Arch 454:879~889
Qu Z / 2004 / Mouse bestrophin-2is a bona fide Cl(-) channel: identification of a residue important in anion binding and conduction / J Gen Physiol 123:327~340
Petrukhin K / 1998 / Identification of the gene responsible for Best macular dystrophy / Nat Genet 19:241~247
Eggermont J / 2004 / Calcium-activated chloride channels:(un)known, (un)loved? / Proc Am Thorac Soc 1:22~27
Kunzelmann K / 2007 / Calcium-dependent chloride conductance in epithelia: is there a contribution by bestrophin? / Pflugers Arch 454:879~889
Qu Z / 2004 / Mouse bestrophin-2is a bona fide Cl(-) channel: identification of a residue important in anion binding and conduction / J Gen Physiol 123:327~340
이 논문의 저자 정보
최근 본 자료
댓글(0)
0