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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 130 - 138 (9page)
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초록· 키워드
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Ischemia can cause decreased cerebral neurovascular coupling, leading to a failure in the autoregulation of cerebral blood flow. This study aims to investigate the effect of varying degrees of ischemia on cerebral hemodynamic reactivity using in vivo real-time optical imaging. We utilized direct cortical stimulation to elicit hyper-excitable neuronal activation, which leads to induced hemodynamic changes in both the normal and middle cerebral artery occlusion (MCAO) ischemic stroke groups. Hemodynamic measurements from optical imaging accurately predict the severity of occlusion in mild and severe MCAO animals. There is neither an increase in cerebral blood volume nor in vessel reactivity in the ipsilateral hemisphere (I.H) of animals with severe MCAO. The pial artery in the contralateral hemisphere (C.H) of the severe MCAO group reacted more slowly than both hemispheres in the normal and mild MCAO groups. In addition, the arterial reactivity of the I.H in the mild MCAO animals was faster than the normal animals. Furthermore, artery reactivity is tightly correlated with histological and behavioral results in the MCAO ischemic group. Thus, in vivo optical imaging may offer a simple and useful tool to assess the degree of ischemia and to understand how cerebral hemodynamics and vascular reactivity are affected by ischemia.
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참고문헌 (28)
참고문헌 신청
Barr TL / 2010 / Genomic biomarkers and cellular pathways of ischemic stroke by RNA gene expression profiling / Neurology 75:1009~1014
Girouard H / 2006 / Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease / J Appl Physiol (1985) 100:328~335
Salinet AS / 2015 / Effects of cerebral ischemia on human neurovascular coupling, CO2reactivity, and dynamic cerebral autoregulation / J Appl Physiol (1985) 118:170~177
Hartman RE / 2005 / Characterizing learning deficits and hippocampal neuron loss following transient global cerebral ischemia in ra / Brain Res 1043:48~56
Bauer AQ / 2014 / Optical imaging of disrupted functional connectivity following ischemic stroke in mice / Neuroimage 99:388~401
Girouard H / 2006 / Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease / J Appl Physiol (1985) 100:328~335
Salinet AS / 2015 / Effects of cerebral ischemia on human neurovascular coupling, CO2reactivity, and dynamic cerebral autoregulation / J Appl Physiol (1985) 118:170~177
Hartman RE / 2005 / Characterizing learning deficits and hippocampal neuron loss following transient global cerebral ischemia in ra / Brain Res 1043:48~56
Bauer AQ / 2014 / Optical imaging of disrupted functional connectivity following ischemic stroke in mice / Neuroimage 99:388~401
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