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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 126 - 132 (7page)
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초록· 키워드
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Background: Tacrolimus (Tac) can cause impaired insulin release and dyslipidemia, and may affect the development of post-transplant diabetes mellitus. However, these effects on insulin sensitivity and lipid profile have not been compared in renal transplant recipients receiving traditional twice-daily tacrolimus (TacBID) or cyclosporine and those receiving once-daily prolonged release formulation of tacrolimus (TacOD). Methods: We conducted an observational prospective study of 15 stable non-diabetic renal transplant recipients to observe the changes in insulin sensitivity and lipid profiles for 1 year at a tertiary hospital. We evaluated the levels of hemoglobin A1c, total cholesterol, high density lipoprotein, low density lipoprotein, triglycerides, apolipoprotein A1, apolipoprotein B, serum creatinine, fasting plasma glucose, fasting insulin, homeostatic model assessment of -cell (HOMA-) and HOMA-insulin resistance index at baseline and at 2 and 4 months. To analyze differences in parameters, we conducted a Wilcoxon rank sum test and general linear model (GLM)-repeated measures analysis of variance (ANOVA) in both groups (cyclosporine to TacOD conversion group/TacBID to TacOD conversion group). Results: At baseline, parameters did not differ between groups. GLM-repeated measures ANOVA revealed no change in insulin sensitivity or lipid profile after conversion at baseline or at 2 and 4 months. There were no complications after conversion from standard TacBID or cyclosporine to TacOD. Conclusions: There was no change in insulin sensitivity or lipid profile in renal transplant recipients. Any conversion from TacBID to TacOD should be performed in a controlled manner under close surveillance.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Bayer ND / 2010 / Association of metabolic syndrome with development of new-onset diabetes after transplantation / Transplantation 90:861~866
Ali IH / 2011 / Incidence and risk factors for post-renal transplant diabetes mellitus / Transplant Proc 43:568~571
Cosio FG / 2005 / New onset hyperglycemia and diabetes are associated with increased cardiovascular risk after kidney transplantation / Kidney Int 67:2415~2421
Midtvedt K / 2011 / No change in insulin sensitivity in renal transplant recipients converted from standard to once-daily prolonged release tacrolimus / Nephrol Dial Transplant 26:3767~3772
Guirado L / 2011 / Efficacy and safety of conversion from twice-daily to once-daily tacrolimus in a large cohort of stable kidney transplant recipients / Am J Transplant 11:1965~1971
Ali IH / 2011 / Incidence and risk factors for post-renal transplant diabetes mellitus / Transplant Proc 43:568~571
Cosio FG / 2005 / New onset hyperglycemia and diabetes are associated with increased cardiovascular risk after kidney transplantation / Kidney Int 67:2415~2421
Midtvedt K / 2011 / No change in insulin sensitivity in renal transplant recipients converted from standard to once-daily prolonged release tacrolimus / Nephrol Dial Transplant 26:3767~3772
Guirado L / 2011 / Efficacy and safety of conversion from twice-daily to once-daily tacrolimus in a large cohort of stable kidney transplant recipients / Am J Transplant 11:1965~1971
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