지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 315 - 322 (8page)
이용수
초록· 키워드
오류제보하기
The high mortality rates associated with acute kidney injury are mainly due to extra-renal complications that occur following distant-organ involvement. Damage to these organs, which is commonly referred to as multiple organ dysfunction syndrome, has more severe and persistent effects. The brain and its sub-structures, such as the hippocampus, are vulnerable organs that can be adversely affected. Acute kidney injury may be associated with numerous brain and hippocampal complications, as it may alter the permeability of the blood-brain barrier. Although the pathogenesis of acute uremic encephalopathy is poorly understood, some of the underlying mechanisms that may contribute to hippocampal involvement include the release of multiple inflammatory mediators that coincide with hippocampus inflammation and cytotoxicity, neurotransmitter derangement, transcriptional dysregulation, and changes in the expression of apoptotic genes. Impairment of brain function, especially of a structure that has vital activity in learning and memory and is very sensitive to renal ischemic injury, can ultimately lead to cognitive and functional complications in patients with acute kidney injury. The objective of this review was to assess these complications in the brain following acute kidney injury, with a focus on the hippocampus as a critical region for learning and memory.
목차
등록된 정보가 없습니다.
참고문헌 (55)
참고문헌 신청
Malek M / 2014 / The preventive effects of diminazene aceturate in renal ischemia/reperfusion injury in male and female rats / Adv Prev Med 2014:740647
Chang CH / 2014 / Acute kidney injury enhances outcome prediction ability of sequential organ failure assessment score in critically ill patients / PLoS One 9:e109649
Malek M / 2015 / Renal ischemia/reperfusion injury; from pathophysiology to treatment / J Renal Inj Prev 4:20~27
Yap SC / 2012 / Acute kidney injury and extrarenal organ dysfunction: new concepts and experimental evidence / Anesthesiology 116:1139~1148
Chertow GM / 1998 / Predictors of mortality and the provision of dialysis in patients with acute tubular necrosis / J Am Soc Nephrol 9:692~698
Chang CH / 2014 / Acute kidney injury enhances outcome prediction ability of sequential organ failure assessment score in critically ill patients / PLoS One 9:e109649
Malek M / 2015 / Renal ischemia/reperfusion injury; from pathophysiology to treatment / J Renal Inj Prev 4:20~27
Yap SC / 2012 / Acute kidney injury and extrarenal organ dysfunction: new concepts and experimental evidence / Anesthesiology 116:1139~1148
Chertow GM / 1998 / Predictors of mortality and the provision of dialysis in patients with acute tubular necrosis / J Am Soc Nephrol 9:692~698
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