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학술저널
저자정보
이경희 (Department of Internal Medicine Kyungpook National University School of Medicine Daegu Korea) 조장희 (경북대학교) Owen Kwon (Kyungpook National University Hospital) Sang-Un Kim (Kyungpook National University) 김량희 (Department of Internal Medicine Kyungpook National University School of Medicine Daegu Korea) 조영욱 (Department of Internal Medicine Kyungpook National University School of Medicine Daegu Korea) 정희연 (경북대학교병원) 최지영 (Department of Internal Medicine Kyungpook National University School of Medicine Daegu Korea) 김찬덕 (경북대학교) 김용림 (경북대학교) 박선희 (경북대학교)
저널정보
대한신장학회 Kidney Research and Clinical Practice Kidney Research and Clinical Practice Vol.35 No.3
발행연도
2016.1
수록면
169 - 175 (7page)

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Background: Prealbumin, a sensitive marker for proteineenergy status, is also known as an independent risk factor for mortality in hemodialysis patients. We investigated the impact of prealbumin on survival in incident peritoneal dialysis (PD) patients. Methods: In total, 136 incident PD patients (mean age, 53.0 ± 15.8 years) between 2002 and 2007 were enrolled in the study. Laboratory data, dialysis adequacy, and nutritional parameters were assessed 3 months after PD initiation. Patients were classified into 2 groups according to prealbumin level: high prealbumin ( 40 mg/dL) and low prealbumin (< 40 mg/dL). Results: The patients in the low-prealbumin group were older and had more comorbidities such as diabetes and cardiovascular diseases compared with the patients in the high-prealbumin group. Mean subjective global assessment scores were lower, and the high-sensitivity C-reactive protein levels were higher in the low-prealbumin group. Serum creatinine, albumin, and transferrin levels; percent lean body mass; and normalized protein catabolic rate were positively associated, whereas subjective global assessment scores and high-sensitivity C-reactive protein levels were negatively associated with prealbumin concentration. During the median follow-up of 49 months, patients in the lower prealbumin group had a higher mortality rate. Multivariate analysis revealed that prealbumin < 40 mg/dL (hazard ratio, 2.30; 95% confidence interval, 1.14e4.64) was an independent risk factor for mortality. In receiver operating characteristic curves, the area under the curve of prealbumin for mortality was the largest among the parameters. Conclusion: Prealbumin levels were an independent and sensitive predictor for mortality in incident PD patients, showing a good correlation with nutritional and inflammatory markers.

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