지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 287 - 295 (9page)
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Background and Objectives We defined laboratory marker profiles typical of incomplete Kawasaki disease (iKD) during illness, especially with respect to the presence of a coronary artery abnormality such as coronary artery dilation or aneurysm. Methods This retrospective study examined the clinical and laboratory markers of patients with iKD over time, along with those of patients with complete KD (cKD) and febrile controls. Results Of 795 patients, 178 had iKD, 504 had cKD and 113 were febrile controls. During the transition from the acute to subacute phase, the age-adjusted hemoglobin levels and platelet counts were significantly lower and higher, respectively, in the subacute phase than in the acute phase in both iKD and cKD patients, which differed from those of febrile controls. Lower levels of acute and subacute age-adjusted hemoglobin levels in iKD patients (odds ratio [OR], 0.538 and 0.583; p=0.006 and 0.018, respectively) and higher subacute platelet counts in cKD patients (OR, 1.004; p=0.014) were correlated with the risk of coronary dilation. A higher acute neutrophil-to-lymphocyte ratio was associated with aneurysm only in cKD patients (OR, 1.059; p=0.044). Conclusions The iKD patients share KD-specific laboratory marker profiles in terms of complete blood cell counts and acute phase reactant levels with cKD patients. However, the factors predicting coronary dilation differ according to the phenotype; lower acute and subacute age-adjusted hemoglobin levels predict coronary dilation only in iKD patients.
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참고문헌 (22)
참고문헌 신청
Newburger JW / 2004 / Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association / Circulation 110:2747~2771
Yellen ES / 2010 / Performance of 2004 American Heart Association recommendations for treatment of Kawasaki disease / Pediatrics 125:e234~e241
Manlhiot C / 2012 / Complete and incomplete Kawasaki disease: two sides of the same coin / Eur J Pediatr 171:657~662
Song D / 2009 / Risk factors for Kawasaki disease-associated coronary abnormalities differ depending on age / Eur J Pediatr 168:1315~1321
Sudo D / 2012 / Coronary artery lesions of incomplete Kawasaki disease: a nationwide survey in Japan / Eur J Pediatr 171:651~656
Yellen ES / 2010 / Performance of 2004 American Heart Association recommendations for treatment of Kawasaki disease / Pediatrics 125:e234~e241
Manlhiot C / 2012 / Complete and incomplete Kawasaki disease: two sides of the same coin / Eur J Pediatr 171:657~662
Song D / 2009 / Risk factors for Kawasaki disease-associated coronary abnormalities differ depending on age / Eur J Pediatr 168:1315~1321
Sudo D / 2012 / Coronary artery lesions of incomplete Kawasaki disease: a nationwide survey in Japan / Eur J Pediatr 171:651~656
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