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학술저널
저자정보
Hajime Fukui (Department of Cell Biology National Cerebral and Cardiovascular Center Research Institute Osaka) Ayano Chiba (Department of Cell Biology National Cerebral and Cardiovascular Center Research Institute Osaka) Takahiro Miyazaki (Department of Cell Biology National Cerebral and Cardiovascular Center Research Institute Osaka) Haruko Takano (Department of Cell Biology National Cerebral and Cardiovascular Center Research Institute Osaka) Hiroyuki Ishikawa (Department of Cell Biology National Cerebral and Cardiovascular Center Research Institute Osaka) Naoki Mochiuzki (Department of Cell Biology National Cerebral and Cardiovascular Center Research Institute Osaka) Toyonori Omori (Management office National Center for Child Health and Development Tokyo)
저널정보
대한심장학회 Korean Circulation Journal Korean Circulation Journal Vol.47 No.2
발행연도
2017.1
수록면
160 - 167 (8page)

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Incomplete development and severe malformation of the heart result in miscarriage of embryos because of its malfunction as a pump for circulation. During cardiogenesis, development of the heart is precisely coordinated by the genetically-primed program that is revealed by the sequential expression of transcription factors. It is important to investigate how spatial allocation of the heart containing cardiomyocytes and other mesoderm-derived cells is determined. In addition, the molecular mechanism underlying cardiomyocyte differentiation still remains elusive. The location of ectoderm-, mesoderm-, and endoderm-derived organs is determined by their initial allocation and subsequent mutual cell-cell interactions or paracrine-based regulation. In the present work, we provide an overview of cardiac development controlled by the germ layers and discuss the points that should be uncovered in future for understanding cardiogenesis.

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