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저자정보
Tolga Han Efe (Dışkapı Yıldırım Beyazıt Training and Research Hospital Cardiology Clinic) Çağrı Yayla (Türkiye Yüksek Ihtisas Training and Research Hospital) Burak Açar (Turkiye Yuksek Ihtisas Training and Research Hospital Ankara Turkey) Göktuğ Ertem (Türkiye Yüksek Ihtisas Training and Research Hospital Cardiology Clinic) Kadriye Gayretli Yayla (Dışkapı Yıldırım Beyazıt Training and Research Hospital Cardiology Clinic) Engin Algül (Dışkapı Yıldırım Beyazıt Training and Research Hospital Cardiology Clinic) Sefa Ünal (Türkiye Yüksek Ihtisas Training and Research Hospital Cardiology Clinic) Murat Bilgin (Department of Cardiology Dışkapı Yıldırım Beyazıt Training and Research Hospital Ankara Turkey) Tolga Çimen (Department of Cardiology Dışkapı Yıldırım Beyazıt Training and Research HospitalAnkaraTurkey) Özgür Kirbaş (Türkiye Yüksek Ihtisas Training and Research Hospital Cardiology Clinic) Ekrem Yeter (Department of Cardiology Dışkapı Yıldırım Beyazıt Training and Research Hospital Ankara)
저널정보
대한심장학회 Korean Circulation Journal Korean Circulation Journal Vol.47 No.1
발행연도
2017.1
수록면
44 - 49 (6page)

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Background and Objectives: The recently discovered myokine irisin has a proposed role in adipose tissue metabolism. The aim of this study was to evaluate the relationship between serum irisin level and the coronary artery severity in patients with stable coronary artery disease (CAD). Subjects and Methods: Sixty-three patients who underwent coronary angiography (CA) diagnosed with stable CAD and twenty-six patients with normal coronary artery (NCA) were enrolled in the study. Stable CAD patients were divided into two groups as high synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) score (≥23) and lower SYNTAX score (<23). Serum irisin level measurement was carried out using human irisin colorimetric enzyme-linked immunosorbent assay (ELISA) commercial kit (AG-45A-0046EK-KI01, Adipogen, San Diego, CA, USA) as recommended by the manufacturer’s protocol. Results: The patients with stable CAD with a higher SYNTAX score (score ≥23) had significantly lower serum irisin levels (127.91±55.38 ng/mL), as compared the patients with a low SYNTAX score (score <23) (224.69±92.99 ng/mL) and control group (299.54±123.20 ng/mL). Irisin levels showed significant differences between all groups (p<0.001). Conclusion: Serum irisin level is an independent predictor of coronary artery severity in patients with stable CAD.

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