지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 499 - 506 (8page)
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초록· 키워드
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Background and Objectives: We assessed plaque erosion of culprit lesions in patients with acute coronary syndrome in real world practice. Subjects and Methods: Culprit lesion plaque rupture or plaque erosion was diagnosed with optical coherence tomography (OCT). Intravascular ultrasound (IVUS) was used to determine arterial remodeling. Positive remodeling was defined as a remodeling index (lesion/ reference EEM [external elastic membrane area) >1.05. Results: A total of 90 patients who had plaque rupture showing fibrous-cap discontinuity and ruptured cavity were enrolled. 36 patients showed definite OCT-plaque erosion, while 7 patients had probable OCT-plaque erosion. Overall, 26% (11/43) of definite/probable plaque erosion had non-ST elevation myocardial infarction (NSTEMI) while 35% (15/43) had ST elevation myocardial infarction (STEMI). Conversely, 14.5% (13/90) of plaque rupture had NSTEMI while 71% (64/90) had STEMI (p<0.0001). Among plaque erosion, white thrombus was seen in 55.8% (24/43) of patients and red thrombus in 27.9% (12/43) of patients. Compared to plaque erosion, plaque rupture more often showed positive remodeling (p=0.003) with a larger necrotic core area examined by virtual histology (VH)-IVUS, while negative remodeling was prominent in plaque erosion. Overall, 65% 28/43 of plaque erosions were located in the proximal 30 mm of a culprit vessel-similar to plaque ruptures (72%, 65/90, p=0.29). Conclusion: Although most of plaque erosions show nearly normal coronary angiogram, modest plaque burden with negative remodeling and an uncommon fibroatheroma might be the nature of plaque erosion. Multimodality intravascular imaging with OCT and VH-IVUS showed fundamentally different pathoanatomic substrates underlying plaque rupture and erosion.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Farb A / 1996 / Coronary plaque erosion without rupture into a lipid core: a frequent cause of coronary thrombosis in sudden coronary death / Circulation 93:1354~1363
Virmani R / 2006 / Pathology of the vulnerable plaque / J Am Coll Cardiol 47(8 Suppl):C13~C18
Burke AP / 1998 / Effect of risk factors on the mechanism of acute thrombosis and sudden coronary death in women / Circulation 97:2110~2116
홍영준 / 2015 / Role of Intravascular Ultrasound in Patients with Acute Myocardial Infarction / Korean Circulation Journal 45(4):259~265
Sanidas EA / 2011 / Angioscopic and virtual histology intravascular ultrasound characteristics of culprit lesion morphology underlying coronary artery thrombosis / Am J Cardiol 107:1285~1290
Virmani R / 2006 / Pathology of the vulnerable plaque / J Am Coll Cardiol 47(8 Suppl):C13~C18
Burke AP / 1998 / Effect of risk factors on the mechanism of acute thrombosis and sudden coronary death in women / Circulation 97:2110~2116
홍영준 / 2015 / Role of Intravascular Ultrasound in Patients with Acute Myocardial Infarction / Korean Circulation Journal 45(4):259~265
Sanidas EA / 2011 / Angioscopic and virtual histology intravascular ultrasound characteristics of culprit lesion morphology underlying coronary artery thrombosis / Am J Cardiol 107:1285~1290
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